Optimization of a depth of interaction encoding PET block detector for a PET/MRI insert.

Optimization of a depth of interaction encoding PET block detector for a PET/MRI insert. Phys Med Biol. 2018 Dec 06;63(23):235031 Authors: Selfridge AR, Cherry SR, Judenhofer MS Abstract Preclinical positron emission tomography, combined with magnetic resonance imaging (PET/MRI), is increasingly used as a tool to simultaneously characterize functional processes in vivo. Many emerging preclinical applications, however, are limited by PET detection sensitivity, especially when generating short imaging frames for quantitative studies. One such application is dynamic multifunctional imaging, which probes multiple aspects of a biological process, using relationships between the datasets to quantify interactions. These studies have limited accuracy due to the relatively low sensitivity of modern preclinical PET/MRI systems. The goal of this project is to develop a preclinical PET/MRI insert with detection sensitivity above 15% (250-750 keV) to improve quantitation in dynamic PET imaging. To achieve this sensitivity, we have developed a detector module incorporating a 2 cm thick crystal block, which will be arranged into a system with 8 cm axial FOV, targeting mice and rats. To maintain homogenous spatial resolution, the detector will incorporate dual-ended depth-of-interaction (DOI) encoding with silicon photomultiplier (SiPM) based photodetector arrays. The specific aim of this work is to identify a detector configuration with adequate pe...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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ConclusionsTFA was determined to be a theranostic agent for chemical ablation of solid tissue. Ablation was both efficacious and imageable in ex vivo healthy tissue, even at low concentrations or with high temporal resolution.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 16 September 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Husniye Demirturk Kocasarac, Emine S. Kursun-Cakmak, Gulbahar Ustaoglu, Seval Bayrak, Kaan Orhan, Marcel NoujeimAbstractObjectivesQuantitatively compare the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in T1WI and T2WI sequences in 3 T magnetic resonance imaging (MRI) using zirconium, titanium (grades 4 and 5), and titanium-zirconium alloy implants to evaluate the effect of implant type and imaging sequence.MethodsMRI was acquired using a 3.0 Tesla magnet with a 16-channel he...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsThese results provide evidence that the impaired cognitive flexibility of OCD may be associated with dysfunctions of the brain network from the dorsal caudate (DC) to important nodes of the salience network. Our results extend the neuropsychological model of OCD by showing intrinsically different associations between OCD and HC in functional network and cognitive flexibility.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 14 September 2019Source: European Journal of RadiologyAuthor(s): Thomas Sartoretti, Elisabeth Sartoretti, Michael Wyss, Árpád Schwenk, Luuk van Smoorenburg, Barbara Eichenberger, Arash Najafi, Christoph Binkert, Anton S. Becker, Sabine Sartoretti-ScheferAbstractPurposeTo compare image quality between a 2D T1w turbo spin echo (TSE) sequence and a Compressed SENSE accelerated 3D T1w black blood TSE sequence (equipped with a black blood prepulse for blood signal suppression) in pre- and postcontrast imaging of the pituitary and to assess scan time reductions.Methods and Materia...
Source: European Journal of Radiology - Category: Radiology Source Type: research
ConclusionsMinimal deviation adenocarcinoma represents one of rare cervical adenocarcinomas without HPV-association. While it is crucial to differentiate benign from malignant lesions in this subtype, imaging characteristics often overlap and may not provide a specific diagnosis. Therefore, it should be considered in suspicious multicystic cervical lesions and inconclusive PAP-smear. Definitive diagnosis of this subtype should be based on cervical biopsy.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Authors: Ozaki T, Kinoshita M, Arita H, Kagawa N, Fujimoto Y, Kanemura Y, Sakai M, Watanabe Y, Nakanishi K, Shimosegawa E, Hatazawa J, Kishima H Abstract Brain Tumor Image Analysis (BraTumIA) is a fully automated segmentation tool dedicated to detecting brain tumors imaged by magnetic resonance imaging (MRI). BraTumIA has recently been applied to several clinical investigations; however, the validity of this novel method has not yet been fully examined. The present study was conducted to validate the quality of tumor segmentation with BraTumIA in comparison with results from 11C-methionine positron emission tomogra...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
The objective of this study was to look for compensatory foot and ankle behaviours during gait in paediatric patients with symptomatic ACL deficiency.HypothesisCompensation for ACL deficiency during gait occurs at the foot and ankle in children, because compensation at the hip and pelvis would require greater energy expenditure.Material and methodsWe included 47 patients, 33 males and 14 females, ranging in age from 9 to 17 years (mean, 14.1 years). The patients had a history of unilateral ACL injury documented by MRI and initially treated by immobilisation and physical therapy. They were allowed to walk with full weight-b...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Michalis Kassinopoulos, Georgios D. MitsisAbstractFunctional magnetic resonance imaging (fMRI) is widely viewed as the gold standard for studying brain function due to its high spatial resolution and non-invasive nature. However, it is well established that changes in breathing patterns and heart rate strongly influence the blood oxygen-level dependent (BOLD) fMRI signal and this, in turn, can have considerable effects on fMRI studies, particularly resting-state studies. The dynamic effects of physiological processes are often quantified by using co...
Source: NeuroImage - Category: Neuroscience Source Type: research
AbstractPurposeThe study evaluated the usefulness of magnetic resonance imaging (MRI) texture parameters in differentiating clear cell renal carcinoma (CC-RCC) from non-clear cell carcinoma (NC-RCC) and in the histological grading of CC-RCC.Materials and methodsAfter institutional ethical approval, this retrospective study analyzed 33 patients with 34 RCC masses (29 CC-RCC and five NC-RCC; 19 low-grade and 10 high-grade CC-RCC), who underwent MRI between January 2011 and December 2012 on a 1.5-T scanner (Avanto, Siemens, Erlangen, Germany). The MRI protocol included T2-weighted imaging (T2WI), diffusion-weighted imaging [D...
Source: Abdominal Imaging - Category: Radiology Source Type: research
AbstractPurposeTo evaluate the diagnostic performance of superparamagnetic iron-oxide (SPIO)-enhanced diffusion-weighted image (DWI) for distinguishing an intrapancreatic accessory spleen from pancreatic tumors.Materials and methodsTwenty-six cases of intrapancreatic accessory spleen and nine cases of pancreatic tail tumors [neuroendocrine tumor (n = 8) and pancreatic adenocarcinoma (n  =  1)] were analyzed. Two blind reviewers retrospectively reviewed the SPIO-enhanced magnetic resonance imaging (MRI) scans. The lesion visibility grades were compared and the diagnostic performance of SPIO-enhan...
Source: Abdominal Imaging - Category: Radiology Source Type: research
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