Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized 13C-MRSI

Conclusions: Our workflow allows the quantification of simultaneously acquired PET, MRSI and DWI data in rodents on a clinical PET/MR scanner. The correlations and findings suggest that a major portion of consumed glucose is metabolized by aerobic glycolysis in the investigated tumor model. Furthermore, we conclude that variations in cell density affect PET and 13C-data in a similar manner and correlations of longitudinal metabolic data appear to reflect both biochemical processes and tumor cellularity.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Christian Hundshammer, Miriam Braeuer, Christoph A. M ü ller, Adam E. Hansen, Mathias Schillmaier, Stephan D ü wel, Benedikt Feuerecker, Steffen J. Glaser, Axel Haase, Wilko Weichert, Katja Steiger, Jorge Cabello, Franz Schilling, Jan-Bernd H ö vener, Tags: Research Paper Source Type: research