In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis

Conclusion: Dextran-Catechin mediates its activity by lowering CTR1 and intracellular copper levels in tumors. This finding further reveals a potential therapeutic strategy for targeting copper-dependent cancers and presents a novel PET imaging method to assess patient response to copper-targeting anticancer treatments.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Arvind Parmar, Giancarlo Pascali, Florida Voli, Luigi Lerra, Eugene Yee, Aria Ahmed-Cox, Kathleen Kimpton, Giuseppe Cirillo, Andrew Arthur, David Zahra, Gita Rahardjo, Guo Jun Liu, Nigel Lengkeek, Federica Saletta, Arnaud Charil, Maria Kavallaris, Orazio Tags: Research Paper Source Type: research