The prognostic significance of androgen receptor and β-catenin immunohistochemical expression in urothelial carcinoma with and without detrusor muscle invasion from an Egyptian institution.

This study investigated the prognostic significance of AR and β-catenin expression and their relationship to different clinic-pathological parameters, recurrence free and progression free survival. 106 urothelial carcinoma cases were used to study the immunohistochemical expression of AR and β-catenin. Log-Rank test to compare survival between groups. Androgen receptor positivity was in 37 (34.9%) cases. Both aberrant β-catenin and AR positivity were associated with higher tumor grade (p = 0.033 and p = 0.037 respectively) and muscle invasion (p = 0.007 and p = 0.039 respectively). Aberrant β-catenin only showed statistically significant association with tumor diameter (p = 0.036), tumor stage (p = 0.038), LN metastasis (p = 0.001), tumor recurrence (p = 0.026) and tumor progression (p = 0.01). Cases with aberrant β-catenin showed higher AR positivity (p = 0.018). Our study highlighted important information about the link between Wnt/β-catenin and AR pathway during the progression of transitional urothelial carcinoma with aberrant β-catenin could be used as a prognostic marker. PMID: 30509050 [PubMed - in process]
Source: Polish Journal of Pathology - Category: Pathology Tags: Pol J Pathol Source Type: research