Famous books in the history of pathology.
Authors: Tweel JGVD PMID: 31556544 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

New life to Italian university anatomical collections: desire to give value and open museological issues. Cases compared.
This article provides an overview of museological issues in the anatomical area in order to offer ideas and visions, from a comparison of three different examples: the Museum of Human Anatomy of the University of Pavia, the Museum of Pathological Anatomy at the University of Padua and the Gordon Museum of Pathology in London. PMID: 31556545 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

From magnifying glass to operative microscopy - the historical and modern role of the microscope in microsurgery.
Authors: Liczbik O, Goertz S, Wiśniewski J, Kurlandt P, Libionka W, Adamski S, Kloc W Abstract The modern computer-assisted microscope, being a hallmark of microsurgery, has become a standard piece of equipment in the operating theatre. Its introduction enabled visualisation of fine anatomical structures, obscure to the unaided eye, and revolutionised many surgical specialties, such as neurological, ophthalmological, or vascular. These astounding achievements have been the culmination of a century of constant progress in optical engineering and microsurgery, since 1921, when a microscope was first used during surg...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Environment and urinary bladder cancer. A historical perspective.
Authors: Nesi G, Galli IC, Amorosi A, Santi R Abstract Our understanding of aetiological factors associated with urinary bladder cancer has radically improved over the last decades. Cigarette smoking is considered the most important risk factor, even in the industrialised world, while various occupational and environmental exposures to chemicals are also held responsible. The link between bladder cancer and schistosomiasis, highly prevalent in sub-Saharan Africa, Sudan, Egypt, and Yemen, provides input for investigating and potentially preventing bladder carcinogenesis. Growing concern regarding environmental disea...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Atypical melanocytic lesions: a historical overview.
Authors: Manchi M, Canzonieri V Abstract The distinction between atypical Spitz lesions, conventional melanocytic nevi including Spitz nevi, and malignant melanomas may be difficult in some cases or may even be impossible. The histological assessment of these lesions is necessary to ensure correct diagnosis and treatment. Nevertheless, pathologists may be subject to suboptimal concordance in the diagnosis of some atypical lesions. In literature, certain atypical lesions have been defined differently: the terms atypical and metastasising Spitz tumour, malignant Spitz nevus, borderline and intermediate melanocytic tu...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Limb body wall complex - the history of the entity and presentation of our series of cases.
We present an analysis of two first historically documented limb body wall complex (LBWC) cases and our own contemporary perinatal autopsy series of this rare complex. So far it was supposed that the first case of this complex was reported in 1685 by Paul Portal. Studying the Joachim Oelhaf's autopsy report from 1613 with attached engraving showing the neonate with multiple birth defects led our research team to a conclusion that it was genuinely the first description of LBWC in the medical literature so far. We compared the Oelhaf's case from 1613 and the Portal's autopsy report from 1685 with our series of LBWC cases dis...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Chorangioma and John Clarke.
Authors: Gouveia R, Silva B, Corte-Real F PMID: 31556550 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Paleopathology of soft tissues: what mummies can reveal.
Authors: Fernández PL, Esteban J, Franco A Abstract Paleopathology is a science located in a crossroad between history, archaeology, anthropology, and medicine an can offer unique historical knowledge by using techniques of traditional pathology as well as other branches of Medicine, which is especially fruitful when applied to ancient subjects in which soft tissues are preserved: mummies. PMID: 31556551 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

"Uninvited guests" of the brain in a 19th-century museum.
"Uninvited guests" of the brain in a 19th-century museum. Pol J Pathol. 2019;70(1):49-50 Authors: Gouveia R, Aguiar MJ, Ferreira T, Carvalho L PMID: 31556552 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Anatomopathological research in nineteenth-century Gda ńsk - an outline of the problem.
Anatomopathological research in nineteenth-century Gdańsk - an outline of the problem. Pol J Pathol. 2019;70(1):51-56 Authors: Szarszewski A, Paluchowski P, Gulczyński J Abstract Between 1793 and 1914, there were many internationally recognised physicians active in Gdansk. Their scientific activities included, among other things, anatomopathological research, constituting a determinant of progress in medical sciences during this period. One of the most important people was Martin Heinrich Rathke (1793-1860). He is recognised as one of the founders of modern embryology. In Gdansk Rathke's successor wa...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Autopsy in European art of  the last five hundred years. A short story.
Autopsy in European art of the last five hundred years. A short story. Pol J Pathol. 2019;70(1):57-61 Authors: Nieczyporowski R PMID: 31556554 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Quiz. What is your diagnosis?
Authors: Fernández PL PMID: 31556555 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

CD117 expression is correlated with poor survival of patients and progression of lung carcinoma:a meta-analysis with a panel of 2645 patients.
Authors: Guo YN, Liang L, Ren S, Wu M, Shi DC, Mo WJ, Chen G Abstract The aim of this research was to investigate the clinical role and prognostic value of CD117 expression assessed immunohistochemically in lung carcinoma through a comprehensive meta-analysis in which 27 publications were acquired and 2645 patients were ultimately analysed. Statistical analysis and corresponding plots were performed using STATA version 12.0. Publication bias was assessed by Begg's funnel plots and Egger's test. Pooled HR and its 95% CI (HR = 1.53, 95% CI: 1.13-2.07, p = 0.007) for overall survival of p...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Long-term follow-up in children with progressive familial intrahepatic cholestasis type 2 after partial external biliary diversion with focus on histopathological features.
We examined retrospectively 8 liver biopsies from 4 PFIC2 patients comparing the results from the first biopsies done at the time of PFIC diagnosis and the second ones, done many years after PEBD. The characteristic lobular rosette formations of hepatocytes were found in all patients at the time of diagnosis. Cholestasis was observed in each patient, but only in two of them, centrally located bile plugs were found. The majority of hepatocytes showed degenerative changes from mild to severe degree. In the follow-up biopsies, cholestasis completely disappeared in 3 patients and decreased significantly in 1 other patient. Bas...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Hypoxia-inducible factor 1 α in combination with vascular endothelial growth factor could predict the prognosis of postoperative patients with oesophageal squamous cell cancer.
Hypoxia-inducible factor 1α in combination with vascular endothelial growth factor could predict the prognosis of postoperative patients with oesophageal squamous cell cancer. Pol J Pathol. 2019;70(2):84-90 Authors: Shao JB, Li Z, Zhang N, Yang F, Gao W, Sun ZG Abstract The purpose of the study is to investigate the clinicopathological and prognostic features of dual hypoxia-inducible factor 1a (HIF-1a) and vascular endothelial growth factor (VEGF) expression in oesophageal squamous cell carcinoma (OSCC) patients. A total of 73 patients were enrolled in this study. The positive expression of HIF-...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Association of breast cancer grade with response to neoadjuvant chemotherapy assessed postoperatively.
Authors: Jarząb M, Stobiecka E, Badora-Rybicka A, Chmielik E, Kowalska M, Bal W, Polakiewicz-Gilowska A, Bobek-Billewicz B, Lange D, Tarnawski R Abstract Currently, breast cancer chemotherapy response can be predicted based on various parameters, with common reporting of tumour grade and Ki67 proliferation index. We analysed their association with pathological complete response (pCR) in a multivariate approach. The study was carried out in a group of 353 patients, treated by preoperative chemotherapy and prospectively observed. In selected patients, parallel to routing core needle biopsy assessment, gene...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

High-grade non-small cell lung carcinoma: a comparative analysis of the phenotypic profile in small biopsies with the corresponding postoperative material.
Authors: Szade J, Majewska HI, Żaczek AJ, Biernat W Abstract The most recent classification of the lung cancer expanded the diagnostic criteria of its histological subtypes and included its immunophenotypic profile. We performed the study to compare the reliability of selected markers in high-grade non-small cell lung carcinoma (NSCLC) in the oligobiopsies with the matched postoperative samples. We evaluated expression of p40, p63, TTF1, cytokeratin 5/6, cytokeratin 7, napsin A, desmoglein 3, desmocollin 3 and mucin secretion as detected by mucicarmine staining. The study cohort included 123 cases of poorly-differ...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

CD11c- and CD123-positive dendritic cells in development of antitumour immunity in non-small cell lung cancer patients.
In conclusion results suggest that CD11c- and CD123-positive DCs play an important role in antitumour immunity and can be predictive factor for tumour development in patients with NSCLC. PMID: 31556561 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Somatic mutations in BRCA1 & 2 in 201 unselected ovarian carcinoma samples - single institution study.
Somatic mutations in BRCA1&2 in 201 unselected ovarian carcinoma samples - single institution study. Pol J Pathol. 2019;70(2):115-126 Authors: Kowalik A, Zalewski K, Kopczyński J, Siołek M, Lech M, Hińcza K, Kalisz J, Chrapek M, Zięba S, Furmańczyk J, Jedliński M, Chłopek M, Misiek M, Góźdź S Abstract Ovarian cancer (OC) is the most lethal among gynecologic malignancies worldwide. Unfortunately, in around 70% of cases cancer is diagnosed in late stages (III-IV) which decreases the 5-year survival rate to 25%. The standard of care in ovarian cancer is debulki...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

G84E germline mutation in HOXB13 gene is associated with increased prostate cancer risk in Polish men.
Authors: Heise M, Jarzemski P, Bąk A, Junkiert-Czarnecka A, Pilarska-Deltow M, Haus O Abstract We tested the association between HOXB13 G84E (rs138213197) germline mutation and PC risk in Polish men. DNA from 103 consecutive, newly diagnosed patients hospitalised because of PC and DNA from 103 men: volunteers, healthy at the time of the study. The G84E mutation was genotyped using Sanger sequencing. The HOXB13 G84E germline mutation was detected in 2.9% of PC men (3/103) and not detected in any healthy man. Two mutation carriers originated from two of 25 families fulfilling hereditary prostate cancer criteria (HPC...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Cigarette smoking intensifies tendinopathy of the LHBT. A microscopic study after arthroscopic treatment.
Authors: Zabrzyński J, Szukalski J, Paczesny Ł, Szwedowski D, Grzanka D Abstract Smoking has a damaging effect on the musculoskeletal system, which was presented by authors in the rotator cuff and Achilles tendons studies; however, there are a lack of data about the effect of smoking on disorders of the long head of the biceps tendon (LHBT), particularly at the microscopic level. The purpose of this study was to investigate the effect of the tobacco smoking on the histopathologic alterations of the LHBT. Thirty-six patients with preoperatively diagnosed tendinopathy of the LHBT were referred to the Orth...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis.
We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune...
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Diagnosing MERRF requires clinical and genetic evidence.
Authors: Felczak P, Stępniak I, Kowalski P, Stępień T, Wierzba-Bobrowicz T PMID: 31556566 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Liver pathology in hepato-cerebral mitochondrial depletion syndromes due to POLG1, DGUOK, 146or MPV17 variants.
Authors: Finsterer J PMID: 31556567 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Benign-looking primary fibrosarcoma of the uterus.
We present a case of a 38 years-old woman, whose benign looking uterine mass was primary diagnosed as a sclerosing leiomyoma. However, the tumor relapsed in two years with multisite metastases in the abdomen. The complex differential diagnosis excluded the most common mesenchymal tumors of the gynecological tract. Finally, we diagnosed the tumor as an epithelioid sclerosing fibrosarcoma arising from the uterine. PMID: 31556568 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Quiz. What is your diagnosis?
Authors: Strus M, Rajtar-Ciosek A, Jach R, Hankus J, Szczepański W PMID: 31556569 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - September 28, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Liver sinusoidal endothelial cells in morphogenesis of pediatric autoimmune hepatitis. Ultrastructural characteristics - a novel report.
Authors: Łotowska JM, Sobaniec-Łotowska ME, Sobaniec P, Lebensztejn DM Abstract The pathogenesis of autoimmune hepatitis (AIH) is poorly understood. Up to now, little is known of the involvement of liver sinusoidal endothelial cells (LSECs), accounting for approximately 40% of nonparenchymal hepatic cells, in AIH morphogenesis in pediatric patients. The study objective was ultrastructural analysis of LSECs from pretreatment biopsies of 19 children, aged 4-17 years (14 girls), with clinically and histologically diagnosed AIH. Our study is the first to describe alterations in LSECs, from swelling to necrosis, demon...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Distribution of CXCR4 and tumour-infiltrating lymphocytes in breast cancer subtypes; their relationship with each other, axillary lymph node involvement, and other prognostic indicators.
Authors: Pehlivan FS, Sivrikoz ON, Dag F, Kececi SD, Sanal SM Abstract We have investigated the distribution of chemokine receptor 4 (CXCR4) and CD8-positive, tumour-infiltrating T lymphocytes (CD8+ TILs) in breast cancer subtypes and explored the relationship between them and the well-established conventional prognostic markers, including axillary lymph node involvement. A total of 250 breast cancer patients were included in the study. The patients were separated into luminal A+B, HER2 enriched/overexpressed (HER2+), and triple- negative, on the basis of their staining characteristics, via conventional staining me...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Searching for new breast cancer-associated genes. ABRAXAS1 gene mutations in the group of BRCA1-negative patients.
Authors: Bąk A, Junkiert-Czarnecka A, Heise M, Januchowska D, Krzywińska O, Haus O Abstract In the present study, we analysed the association of mutations of a BRCA1-associated gene, ABRAXAS1, with the risk of development of breast cancer (BC) in BRCA1-negative women from North-Central Poland. A hundred women with consecutively diagnosed BC and 100 women belonging to the control group were screened for new mutations predisposing to breast cancer. The first step was a test carried out in order to find one of the three Polish founder mutations in the BRCA1 gene. In 96 BRCA1-negative patients two missense variants: ...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

BRCA1 and PARP1 mRNA expression during progression from normal breast to ductal carcinoma in situ and invasive breast cancer: a laser microdissection study.
Authors: Hybiak J, Domagala P, Domagala W Abstract The contribution of DNA damage repair mechanisms to the progression of normal breast to ductal carcinoma in situ (DCIS) and invasive ductal carcinoma is largely unknown. The purpose of this report was to assess the mRNA expression levels of two important genes associated with DNA repair, BRCA1 and PARP1, in normal breast tissue, DCIS G1, G2 and G3, and co-existing adjacent invasive ductal carcinoma. BRCA1 and PARP1 mRNA expression was assessed in 32 ductal carcinomas in situ of the breast using a laser microdissection and pressure catapulting system and quantitativ...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

EGOT lncRNA in head and neck squamous cell carcinomas.
In this study, we focused on eosinophil granule ontogeny transcript (EGOT), a transcriptional regulator of granule protein expression during eosinophil development that has been previously associated with cancers. Expression levels of EGOT and other selected genes as well as clinical pathology data from HNSCC samples, were obtained from The Cancer Genome Atlas (TCGA) and analysed using GraphPad Prism 5. Our results indicated that the expression of EGOT is slightly down-regulated in HNSCC, depending on tumour grade and location, and is only up-regulated in grade 4 tumours and those located in the pharynx. EGOT expression le...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Histological heterogeneity and distributional difference of gastric carcinosarcoma: report of 4 cases and literature review.
We reported clinicopathologic features of 4 cases and analysis of 76 cases published in the literature. Clinical symptoms were nonspecific with epigastric pain, weight loss, and melena, as the most common complaints. The prognosis of patients was dismal with high mortality. The tumor commonly occurred in the upper stomach in Chinese patients, whereas, it was more prevalent at the lower stomach in Japanese and other populations. The two malignant components of this rare cancer showed considerable histological heterogeneity with a wide range of differentiation. We propose that carcinosarcomas be divided in two main subtypes:...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

The incidence of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene 376fusion in Saudi adult patients with renal cancer: a retrospective tissue microarray analysis.
This study aims to evaluate the frequency of RCC with Xp11.2 in a subset of Saudi adult patients with RCC. 112 RCCs diagnosed in 1995-2016 were retrieved from the Department of Pathology at King Abdulaziz University and King and Faisal Specialist Hospital and Research Centre, Saudi Arabia. Tissue microarrays were constructed and TFE3 immunostaining was performed. TFE3 immunostaining was considered positive when diffuse strong nuclear immunostaining was detected. TFE3 immunostaining-positive tumours were confirmed by fluorescence in situ hybridisation. 4.5% of RCCs were shown to be Xp11.2 RCC by TFE3 immunostaining. TFE3-po...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Various patterns of acute alveolar haemorrhage in patients with microscopic polyangiitis: a clinicopathological study of four cases.
Authors: Kuroda N, Yorita K, Sakamoto K, Tsuji K Abstract It is well known that acute alveolar haemorrhage (AAH) is attributed to capillaritis in most cases with microscopic polyangiitis (MPA). In this article, we explore the cause of alveolar haemorrhage in MPA patients. In the present study, we extracted four autopsy cases of MPA with AAH. Patient's sex and age, cause of alveolar haemorrhage, therapy, follow-up duration, and cause of death were investigated. As a result, alveolar haemorrhage was caused by diffuse alveolar damage (DAD) due to candidiasis or influenza virus infection, haemorrhagic infarct due to as...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Steatosis influences hepatocytes proliferative potential in chronic hepatitis C patients.
Authors: Gabriel A, Kukla M, Adamek B, Tabor K, Banasik G, Horyniecki M, Halota W Abstract The study evaluates the influence of steatosis on hepatocytes proliferative potential, reflected by proliferating cell nuclear antigen (PCNA) expression in chronic hepatitis C (CHC) patients both in steatotic and non-steatotic areas of lobules. The liver histology was evaluated according to Kleiner's score. Nonalcoholic steatohepatitis (NASH) was also defined as the presence of lobular inflammation, hepatocyte ballooning and steatosis. Expression of PCNA was significantly in patients with definite NASH compared to those with ...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

HIF-1 α expression is inversely associated with tumor stage, grade and microvessel density in urothelial bladder carcinoma.
HIF-1α expression is inversely associated with tumor stage, grade and microvessel density in urothelial bladder carcinoma. Pol J Pathol. 2018;69(4):395-404 Authors: Fus ŁP, Pihowicz P, Koperski Ł, Marczewska JM, Górnicka B Abstract Urothelial bladder carcinoma (UBC) is the most common urinary tract malignancy. The most important histopathological factors affecting prognosis are cancer stage and grade. Studies show that microvessel density (MVD) reflecting angiogenesis is also associated with clinicopathological features and affects the outcome in UBC. One of the most important regulators...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Association of ABCB1 T-129C polymorphism and multiple myeloma risk in Polish population.
Authors: Niebudek K, Balcerczak E, Mirowski M, Żebrowska M Abstract The possible interaction between gene polymorphism and cancer risk development is a very interesting issue. The genetic variants of the ATP-binding cassette superfamily B member 1 (ABCB1) are known to be involved in developing cancer risk and individual differences in chemotherapeutic response. Polymorphisms may affect the reduction of the activity and/or expression of important protective cellular proteins. The increased exposure to toxic compounds, including carcinogens is associated with an increased risk of developing cancers. The present stud...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Comet assay is not useful to predict normal tissue response after radiochemotherapy in cervical and larynx cancer patients.
Authors: Adamczyk A, Biesaga B, Klimek M, Mucha-Małecka A Abstract Normal tissues reactions after radiotherapy vary considerably even between patients receiving the same treatment. The ability to predict the differences in radiosensitivity before radiotherapy would have important implication. Patients with squamous cell carcinoma of the: (i) cervix (38 patients) and (ii) larynx (19 patients) were studied. Control group consisted of 9 healthy women. To assess individual radiosensitivity/chemoradiosensitivity alkaline version of comet assay was performed using isolated peripheral blood lymphocytes from cancer patien...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Pathology of skeletal muscle fibers and small blood vessels in MERRF syndrome: an ultrastructural study.
Authors: Felczak P, Stępniak I, Kowalski P, Stępień T, Wierzba-Bobrowicz T Abstract Our studies concerned skeletal muscle biopsy specimens from a patient with clinically suspected MERRF syndrome, confirmed by genetic tests showing the presence of point mutation in the m.8344A> G in the tRNALys gene. Ultrastructurally, extensive damage of mitochondria in skeletal muscle fibres was observed, including the presence of two types of mitochondrial inclusions. Mild damage of mitochondria was revealed in small blood vessels and the presence of calcium deposits in the vascular walls were observed. The differences in m...
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Human pulmonary dirofilariasis disguising as a lung tumour.
We described a case of pulmonary dirofilariasis of a 40-year-old woman, presenting with cough and haemoptysis for one week. It is a rare zoonotic disease in human beings, usually caused by incidental infection of Dirofilaria immitis. PMID: 30786694 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

Quiz. What is your diagnosis?
Authors: Braun M, Kuncman W, Szumera-Ciećkiewicz A, Koseła-Paterczyk H, Musiał J, Kupnicka DJ, Ryś J, Kordek R PMID: 30786695 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - February 23, 2019 Category: Pathology Tags: Pol J Pathol Source Type: research

In memoriam: Professor Olga Mioduszewska.
Authors: Porwit A, Ziarkiewicz-Wróblewska B, Walewski J PMID: 30509046 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research

Membranous glomerulonephritis - a common, unspecific pattern of glomerular injury.
Authors: Starzyńska-Kubicka A, Perkowska-Ptasińska A, Górnicka B Abstract Membranous nephropathy (MN) is a chronic form of glomerulonephritis, associated with the presence of immune complexes beneath the podocytes on the subepithelial region of glomerular capillaries. MN is not a disease entity but one of relatively common patterns of glomerular injury that may be a manifestation of primary renal autoimmunological reaction or may evolve as a phenomenon secondary to wide spectrum of systemic processes. PMID: 30509047 [PubMed - in process] (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research

Low-grade fibromyxoid sarcoma of the extremities: a clinicopathologic study of 24 cases and review of the literature.
Authors: Sambri A, Righi A, Tuzzato G, Donati D, Bianchi G Abstract Low-grade fibromyxoid sarcoma (LGFMS) and hybrid sclerosing epithelioid fibrosarcoma (SEF)/LGFMS have a low potential for recurrence (10%) and metastasis (5%) but they are notorious for late occurring metastases. The aim of this study was to evaluate the outcome of LGFMS and review similar cases reported in the literature. We retrospectively evaluated 24 LGFMS operated at a single Institution. All cases were histologically revised. Mean age was 34 years (range, 8 to 74). Two cases presented areas of SEF (hybrid tumours). Three patients presented wi...
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research

Clinicopathological characteristics of breast sebaceous adenocarcinoma.
Authors: Heng C, Wei T, Yingbing T, Hanzhong L Abstract Two middle-aged females presented with a mass located in the lateral quadrant of the breast. Both patients received modified radical surgery for breast cancer, radiotherapy, and chemotherapy and have been living without evidence of disease for more than one year. Under the microscope, we observed that the tumour cells were organised in a solid nest-like or leafy distribution and comprised sebaceous gland cells and oval or fusiform cells. The differences between the two cases are as follows: First, the mass in the first case had a mixed echo pattern on ultrasou...
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research

The prognostic significance of androgen receptor and β-catenin immunohistochemical expression in urothelial carcinoma with and without detrusor muscle invasion from an Egyptian institution.
This study investigated the prognostic significance of AR and β-catenin expression and their relationship to different clinic-pathological parameters, recurrence free and progression free survival. 106 urothelial carcinoma cases were used to study the immunohistochemical expression of AR and β-catenin. Log-Rank test to compare survival between groups. Androgen receptor positivity was in 37 (34.9%) cases. Both aberrant β-catenin and AR positivity were associated with higher tumor grade (p = 0.033 and p = 0.037 respectively) and muscle invasion (p = 0.007 and p = 0.039 respectively). Aberrant β-catenin on...
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research

Primary ameloblastic carcinoma: literature review with case series.
Authors: Mahmoud SAM, Amer HW, Mohamed SI Abstract Ameloblastic carcinoma (AC) is an extremely rare malignant odontogenic tumour arising from odontogenic epithelium. It was classified into primary type and secondary type. A previous study revealed that primary ameloblastic carcinoma cases were associated with more favourable prognosis than secondary cases. The aim of the present work was: to report the clinical, histopathological, immunohistochemical, and ploidy status, and therapeutic details of four cases of primary AC, and to review the literature with regard to clinical, follow-up, prognosis, histopathological,...
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research

Increased angiogenesis seems to correlate with inferior overall survival in myeloid sarcoma patients.
In this study we explored whether microvessel density, a biomarker of angiogenesis, might be relevant in MS. We studied 60 MS, 24 acute myeloid leukemia, 5 normal bone marrow samples and 2 cases of extramedullary hemopoiesis in patients without evidence of hematological malignancy. We used immunohistochemistry (anti-CD34) to identify and quantify micro-vessel density (MVD) and micro-vessel grading (MVG). We found that MS had significantly higher MVD and MVG than normal bone marrow (p = 0.0002 and p
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research

Effect of sinapic acid on memory deficits and neuronal degeneration induced by intracerebroventricular administration of streptozotocin in rats.
Authors: Shahmohamady P, Eidi A, Mortazavi P, Panahi N, Minai-Tehrani D Abstract The present study aimed to elucidate the neuroprotective effect of sinapic acid on intracerebroventricular streptozotocin (ICV-STZ) induced neuronal loss and memory impairment. To test this hypothesis, male Wistar rats were randomly divided into 11 groups: normal control, sham-operated control, sinapic acid (2.5, 5, 10, and 20 mg/kg bw intragastrically, daily) alone, Alzheimer control rats (ICV-STZ, 3 mg/kg bw), sinapic acid (2.5, 5, 10, and 20 mg/kg bw intragastrically, daily) together with STZ, and the treatment was performed accordi...
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research

Assessment of diagnostic value of cytological examination in lung carcinoma in own material obtained by EBUS and EUS methods.
Authors: Wiśniewski P, Głogowski M, Olszewski W Abstract The aim of the study was the evaluation of the efficiency of cytological examination of the material obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound bronchoscope-guided fine needle aspiration (EUSB-FNA) methods in the diagnosis of lung carcinoma. The usefulness was also assessed of the material obtained in that way for immunocytochemical and molecular tests in the diagnosis of non-small cell lung carcinoma. The material included cytological preparations obtained by EBUS and EUS methods. It w...
Source: Polish Journal of Pathology - December 5, 2018 Category: Pathology Tags: Pol J Pathol Source Type: research