Elevated expression of IGFL1 indicates unfavorable prognosis in lung adenocarcinoma through promotion of cell proliferation and inhibition of apoptosis
This study aimed to determine the potential role of insulin growth factor-like family member 1 (IGFL1) in lung adenocarcinoma (LUAD). We analyzed the expression of IGFL1 using TIMER, UALCAN, and GEPIA. The association of IGFL1 expression with symptoms and overall survival (OS) in LUAD patients was evaluated using a tissue microarray (TMA). Moreover, A549 and H1299 cells with selective IGFL1 knockdown were used to observe their proliferation and apoptosis in vitro. From the TIMER, UALCAN and GEPIA databases, we found that IGFL1 was upregulated in LUAD (p < 0.001). The level of promoter methylation in IGFL1 was significan...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Zhuo Wang Xiaoqin Liang Xiaojun Wang Qin Yu Source Type: research

Prognostic importance of molecular-like classification in gastroesophageal junction tumors (Izmir Oncology Group [IZOG] study)
This study aimed to investigate the clinicopathological and prognostic importance of the classification using immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) to identify potential surrogate markers of molecular changes in gastroesophageal junction (GEJ) adenocarcinomas. A total of 52 GEJ adenocarcinomas were divided into five groups using IHC with MLH-1, E-cadherin, p53 and CISH with EBER: 1) microsatellite unstable (MSI: negative with MLH-1), 2) genomically stable tumors (GS: positive with p53), 3) chromosomally unstable tumors (CUN: negative with e-cadherin), 4) EBV+ tumors (EBV+: positive with EB...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Özlem Özdemir Asuman Argon Sava ş Yakan Tar ık Salman Ahmet AlacacIo ğlu Source Type: research

Lymphocyte-activated gene-3 (LAG3) protein expressed in tumor-infiltrating lymphocytes of colorectal cancer
In this study, we investigated LAG3 protein expression and its correlation with clinicopathologic parameters. The expression of LAG3 protein was assessed in 150 surgically resected colorectal cancer tissue samples by immunohistochemistry. The relationship between LAG3 expression and clinicopathological parameters, MSI status and survival was statistically analyzed. LAG3 protein was not expressed in colorectal cancer cells, and was expressed on the tumor-infiltrating lymphocytes (TILs) in 31 out of 150 (20.7%) colorectal cancer samples. Positive expression of LAG3 in TILs is associated with lymph node metastasis (p < 0.0...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Jianing Xu Dong Shen Ting Zhang Jiandong Wang Wei De Jinsong Zhang Source Type: research

Usefulness of rebiopsy in the case of mesangial pathology
Pol J Pathol. 2021;72(4):331-337. doi: 10.5114/pjp.2021.114178.ABSTRACTImmunologically different types of glomerulopathies show varied symptoms and clinical courses. Unlike in lupus nephritis, repeated biopsy is rarely performed in cases of mesangial glomerulonephritis. We reviewed 200 cases wherein rebiopsy was performed in patients with diagnosed mesangial glomerular pathology over a 30-year period and analyzed the symptoms follow-up in these cases. Further, we evaluated the morphological changes between the first and final biopsies to identify cases of histological progression and histological remission and examined the...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Jakub Żurawski Patrycja Talarska Wies ława Salwa-Żurawska Katarzyna Iwanik Joanna Bulak Aldona Wo źniak Source Type: research

HSP60, SP110 and TNF- α expression in Chlamydia pneumoniae-positive versus Chlamydia pneumoniae-negative atherosclerotic plaques
This study may provide a model for further understanding the mechanisms of Chlamydia pneumoniae atherogenesis and evaluating chlamydial intervention strategies for preventing the advancement of atherosclerotic lesions enhanced by bacterial infections.PMID:35308005 | DOI:10.5114/pjp.2021.114179 (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Nemanja Radojevic Batric Vukcevic Andrea Jovovic Filip Vukmirovic Source Type: research

Wax hearts: seeking the antiquity of cardiac pathology
This study focuses on heart diseases and teaching resources in European university hospitals during the 19th century. It also highlights the importance of wax models in medical education both then and today, in an era of informatics and digital photography.PMID:35308006 | DOI:10.5114/pjp.2021.114182 (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Rosa Henriques de Gouveia Raffaella Santi Roberta Ballestriero Francesco Galassi Lina Carvalho Gabriella Nesi Source Type: research

High mitotic index has no prognostic significance in mixed tumor of the vagina
Pol J Pathol. 2021;72(4):353-355. doi: 10.5114/pjp.2021.114183.ABSTRACTMixed tumor of the vagina is a benign neoplasm usually developing in the posterior and distal vaginal wall, close to the hymen, with almost all reported cases exhibiting no or little cellular pleomorphism and rare mitotic activity. The present paper presents a case of a 30 year-old pregnant patient also known to have human immunodeficiency virus (HIV) infection in which a mixed tumor of the vagina was identified and completely surgically removed. Microscopic examination revealed a predominant spindle cell component characterized by high mitotic activity...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Simona Stolnicu Source Type: research

Endomyocardial biopsy: a 21st century diagnostic tool
Pol J Pathol. 2021;72(4):356-357. doi: 10.5114/pjp.2021.114184.ABSTRACTThe question of the utility of Endomyocardial Biopsy (EMB) often and recurrently raises. It is claimed that the image techniques provide identical results without the risks of an invasive procedure. It is a fact that the impressive technico-scientific development of cardiovascular imagological methodologies covers a broad spectrum of diagnosis. It is also a fact that endomyocardial biopsy is not completely risk-free. Yet, when performed by experienced professionals in reference centres, endomyocardial biopsies my disclose a final unexpected nosologic en...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Rosa Gouveia Maria Andrade Carlos Aguiar S ância Ramos Source Type: research

Primary cardiac atrial sarcomas. Report of two histologically different cases and review of the literature
We report two patients with primary cardiac atrial sarcomas: a case report of a 34-year old woman with intimal sarcoma of the left atrium and a case report of a 30-year old man with synovial sarcoma of the right atrium. Clinicopathological and differential diagnosis with a discussion regarding the role of molecular studies is presented.PMID:35308009 | DOI:10.5114/pjp.2021.114185 (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Miros ława Püsküllüoglu Anna Kruczak Katarzyna Mularz Magdalena Rozmus Agnieszka Harazin-Lechowska Agnieszka Pietruszka Justyna Jaworska Marek Ziobro Aleksandra Grela-Wojewoda Janusz Ry ś Source Type: research

Elevated expression of IGFL1 indicates unfavorable prognosis in lung adenocarcinoma through promotion of cell proliferation and inhibition of apoptosis
This study aimed to determine the potential role of insulin growth factor-like family member 1 (IGFL1) in lung adenocarcinoma (LUAD). We analyzed the expression of IGFL1 using TIMER, UALCAN, and GEPIA. The association of IGFL1 expression with symptoms and overall survival (OS) in LUAD patients was evaluated using a tissue microarray (TMA). Moreover, A549 and H1299 cells with selective IGFL1 knockdown were used to observe their proliferation and apoptosis in vitro. From the TIMER, UALCAN and GEPIA databases, we found that IGFL1 was upregulated in LUAD (p < 0.001). The level of promoter methylation in IGFL1 was significan...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Zhuo Wang Xiaoqin Liang Xiaojun Wang Qin Yu Source Type: research

Prognostic importance of molecular-like classification in gastroesophageal junction tumors (Izmir Oncology Group [IZOG] study)
This study aimed to investigate the clinicopathological and prognostic importance of the classification using immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) to identify potential surrogate markers of molecular changes in gastroesophageal junction (GEJ) adenocarcinomas. A total of 52 GEJ adenocarcinomas were divided into five groups using IHC with MLH-1, E-cadherin, p53 and CISH with EBER: 1) microsatellite unstable (MSI: negative with MLH-1), 2) genomically stable tumors (GS: positive with p53), 3) chromosomally unstable tumors (CUN: negative with e-cadherin), 4) EBV+ tumors (EBV+: positive with EB...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Özlem Özdemir Asuman Argon Sava ş Yakan Tar ık Salman Ahmet AlacacIo ğlu Source Type: research

Lymphocyte-activated gene-3 (LAG3) protein expressed in tumor-infiltrating lymphocytes of colorectal cancer
In this study, we investigated LAG3 protein expression and its correlation with clinicopathologic parameters. The expression of LAG3 protein was assessed in 150 surgically resected colorectal cancer tissue samples by immunohistochemistry. The relationship between LAG3 expression and clinicopathological parameters, MSI status and survival was statistically analyzed. LAG3 protein was not expressed in colorectal cancer cells, and was expressed on the tumor-infiltrating lymphocytes (TILs) in 31 out of 150 (20.7%) colorectal cancer samples. Positive expression of LAG3 in TILs is associated with lymph node metastasis (p < 0.0...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Jianing Xu Dong Shen Ting Zhang Jiandong Wang Wei De Jinsong Zhang Source Type: research

Usefulness of rebiopsy in the case of mesangial pathology
Pol J Pathol. 2021;72(4):331-337. doi: 10.5114/pjp.2021.114178.ABSTRACTImmunologically different types of glomerulopathies show varied symptoms and clinical courses. Unlike in lupus nephritis, repeated biopsy is rarely performed in cases of mesangial glomerulonephritis. We reviewed 200 cases wherein rebiopsy was performed in patients with diagnosed mesangial glomerular pathology over a 30-year period and analyzed the symptoms follow-up in these cases. Further, we evaluated the morphological changes between the first and final biopsies to identify cases of histological progression and histological remission and examined the...
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Jakub Żurawski Patrycja Talarska Wies ława Salwa-Żurawska Katarzyna Iwanik Joanna Bulak Aldona Wo źniak Source Type: research

HSP60, SP110 and TNF- α expression in Chlamydia pneumoniae-positive versus Chlamydia pneumoniae-negative atherosclerotic plaques
This study may provide a model for further understanding the mechanisms of Chlamydia pneumoniae atherogenesis and evaluating chlamydial intervention strategies for preventing the advancement of atherosclerotic lesions enhanced by bacterial infections.PMID:35308005 | DOI:10.5114/pjp.2021.114179 (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Nemanja Radojevic Batric Vukcevic Andrea Jovovic Filip Vukmirovic Source Type: research

Wax hearts: seeking the antiquity of cardiac pathology
This study focuses on heart diseases and teaching resources in European university hospitals during the 19th century. It also highlights the importance of wax models in medical education both then and today, in an era of informatics and digital photography.PMID:35308006 | DOI:10.5114/pjp.2021.114182 (Source: Polish Journal of Pathology)
Source: Polish Journal of Pathology - March 21, 2022 Category: Pathology Authors: Rosa Henriques de Gouveia Raffaella Santi Roberta Ballestriero Francesco Galassi Lina Carvalho Gabriella Nesi Source Type: research