No global increase in resistance to antibiotics: a snapshot of resistance from 2001 to 2016 in Marseille, France

AbstractSince effective empirical antibiotic therapy is a key factor for survival, local antibiotic resistance epidemiology is critical. We aimed to identify current trends in antibiotic resistance for key antibiotics obtained over 16  years (2001–2016) for invasive infections corresponding to empirical treatment in a large hospital centre in Marseille, France.From January 2014 to December 2016, we have collected all data on antibiotic susceptibility from public laboratory hospitals, and a retrospective analysis was performed on key antibiotics in blood cultures since 2001. A total of 99,932 antibiotic susceptibility testings (ASTs) were analysed, and proportion of pan-drug resistant (PDR  = resistant to all antibiotics tested) and extensively drug-resistant (XDR = resistant to all except for two classes) strains were<  0.03 and 0.5%, respectively. Between 2001 and 2016, we found an increase of resistance to third-generation cephalosporins forE. coli invasive strains (0% vs 17.8%;p <  10−5) andK. pneumoniae (8% vs 35.4%;p = 0.001) along with a decrease of methicillin-resistantS. aureus strains (31% vs 19.8%;p = 0.006). Moreover, during the 3-year period, a significant increase of wild-type strains, susceptible to all antibiotics tested, was observed in invasive infections. Regarding bacteraemia involvingEnterobacteriaceae andS. aureus, empirical therapy is effective in>  99% cases. Active epidemiological surveillance is necessary because ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research