Spectrum of Lung Adenocarcinoma

Publication date: Available online 30 November 2018Source: Seminars in Ultrasound, CT and MRIAuthor(s): Barry D. Hutchinson, Girish S. Shroff, Mylene T. Truong, Jane P. KoAbstractLung cancer remains the most common cause of cancer death in the United States of America and worldwide despite continued advances in lung cancer screening as well as surgical, medical and radiation oncological treatments.1 Adenocarcinoma is the most common histological subtype of primary lung cancer,2 accounting for greater than 40% of cases,3 and its relative frequency is increasing.4 The most recent World Health Organization (WHO) Classification of Tumors5 published in 2015 heralded a different approach to lung adenocarcinoma relative to previous editions.6 Various histological subtypes of adenocarcinoma are now organized into a spectrum ranging from indolent preinvasive lesions to aggressive forms of invasive adenocarcinoma with a poor prognosis.2, 6 Increasing emphasis has been placed on the integration of molecular and genetic analysis of adenocarcinomas into the diagnosis and treatment of lung adenocarcinoma owing to the proliferation of novel targeted therapies.6 A correlation between imaging findings in lung adenocarcinoma and histologic features/prognosis has been demonstrated by numerous studies.7, 8, 9 An understanding of the pathology, diagnosis and management of the spectrum of lung adenocarcinoma is more important than ever, considering the central role of the radiologist. The aim of t...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research