Identification and characterization of Prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer's disease

Prokineticin 2 (PROK2) is a peptide that is widely distributed in the nervous system and influences a variety of brain functions, such as pain, food intake and circadian rhythms (Negri and Lattanzi, 2012; Negri and Ferrara, 2018). PROK2 is able to mediate its signaling through two different G-protein coupled receptors (GPCR), designated prokineticin receptor 1 (PKR1) and prokineticin receptor 2 (PKR2) (Masuda et al., 2002; Soga et al., 2002). They activate multiple intracellular signal-transduction pathways promoting intracellular calcium mobilization (Masuda et al., 2002; Negri and Lattanzi, 2012) by G αq coupling; they also induce STAT3 activation coupling to Gαi (especially PKR2) and AMPc production by Gαs proteins (Lin et al., 2002; Negri and Ferrara, 2018; Lattanzi et al., 2018).
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research