miR ‐142‐3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach‐1 expression

ConclusionFor the first time, our results revealed that miR ‐142‐3p could target Bach‐1in breast cancer cells leading to the reduction of EMT‐related proteins and reduced cell proliferation, invasion, and migration. The results also demonstrated that miR‐142‐3p could regulate important tumor suppressor miRNAs in breast cancer cells. In conclusion , our results suggest that miR‐142‐3p could be a good candidate for the targeted therapy of breast cancer, especially for the invasive type.

Source: Journal of Cellular Physiology - November 27, 2018 Category: Cytology Authors: Behzad Mansoori, Ali Mohammadi, Mehri Ghasabi, Solmaz Shirjang, Razeieh Dehghan, Vahid Montazeri, Uffe Holmskov, Tohid Kazemi, Pascal Duijf, Morten Gjerstorff, Behzad Baradaran Tags: ORIGINAL RESEARCH ARTICLE Source Type: research