A Heterozygous Missense hERG Mutation Associated with Early Repolarization Syndrome

Conclusion: Our study indicated that the K801T mutation caused the gain of function of hERG channels that may account for the clinical phenotype of ERS. Quinidine and disopyramide could improve the function of K801T-hERG mutant channel, and may be therapeutic options for patients with the K801T hERG mutation.Cell Physiol Biochem 2018;51:1301 –1312
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research