Sympathetic overactivity in dialysis patients-Underappreciated and clinically consequential.

Sympathetic overactivity in dialysis patients-Underappreciated and clinically consequential. Semin Dial. 2018 Nov 21;: Authors: Hoye NA, Wilson LC, Jardine DL, Walker RJ Abstract Cardiovascular morbidity and mortality remain frustratingly common in dialysis patients. A dearth of established evidence-based treatment calls for alternative therapeutic avenues to be embraced. Sympathetic hyperactivity, predominantly due to afferent nerve signaling from the diseased native kidneys, has been established to be prognostic in the dialysis population for over 15 years. Despite this, tangible therapeutic interventions have, to date, been unsuccessful and the outlook for patients remains poor. This narrative review summarizes established experimental and clinical data, highlighting recent developments, and proposes why interventions to ameliorate sympathetic hyperactivity may well be beneficial for this high-risk population. PMID: 30461070 [PubMed - as supplied by publisher]
Source: Seminars in Dialysis - Category: Urology & Nephrology Authors: Tags: Semin Dial Source Type: research