Improved antioxidant defense in the ventral tegmental area increases pain tolerance in male rats.

In this study, 21 male Sprague-Dawley rats were randomly divided into 2 groups: paired and socially isolated (SI). After one week of acclimatization, the SI rats were isolated for 14 days and the other rats were paired for the same period. On day 15, pain tolerance was assessed through the tail flick test, and two days later the rats were investigated for anxiety in an elevated plus maze (EPM). Indices of oxidative stress (levels of malondialdehyde, glutathione, nitrite/nitrate and catalase activity in the VTA) were then studied in the animals. Malondialdehyde in the VTA was found to be reduced in the SI rats compared with the paired rats. Furthermore, catalase activity, glutathione and nitrite/nitrate levels in the VTA were increased in SI compared with paired rats. Pain tolerance on the tail flick test was increased in SI rats compared with paired rats, while anxiety, as assessed by EPM, was reduced in the SI rats compared with the paired rats. Improvement of antioxidant defense and reduction of oxidative stress in the VTA increases pain tolerance and reduces anxiety. In this sense, environmental conditions play an important role in pain control. PMID: 30457968 [PubMed - in process]
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research

Related Links:

CONCLUSIONS: We confirmed a significant association between inconvenient transportation and unmet healthcare needs among the rural elderly even after adjustment for existing known factors. This implies that policies aimed at improving healthcare accessibility must consider the means of transportation available. PMID: 31795612 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
I once had a neighbor who was very fragile in her age. When I’d ask her how she was doing, she would always respond, “I am counting my blessings. That’s what counts. Things don’t have to be one way all the time. Changes happen and I go with them and laugh instead of growl.” I loved her attitude, even though she was ill and up in years. She was accepting changes with a positive and grateful perspective. “The greatest trap in our life is not success, popularity or power, but self-rejection.” – Henri Nouwen When we struggle with mental, emotional, physical or relationship challe...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Happiness Self-Help Coping Skills grateful Gratitude hope Inspiration Source Type: blogs
International&American Associations for Dental Research Alexandria, VA, USA - 2019 marks the Centennial of theJournal of Dental Research (JDR). Over the last century theJDR has been dedicated to the dissemination of new knowledge and information on all sciences relevant to dentistry and to the oral cavity and associated structures in health and disease. To celebrate, theJDR is featuring a yearlong, commemorative article and podcast series that highlights topics that have transformed dental, oral and craniofacial research over the past 100 years. The importance and value of behavioral sciences in dentistry has long been...
Source: Dental Technology Blog - Category: Dentistry Source Type: news
Conditions:   Anxiety;   Pain;   Venous Puncture Interventions:   Other: Games on an iPad;   Drug: Nitrous Oxide Sponsor:   University Hospital, Geneva Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
___ Life throws chaos at us on a regular basis—whether it’s our finances, our relationships, or our health. In the work world, around 50 percent of people are burned out in industries like health care, banking, and nonprofits, and employers spend $300 billion per year on workplace-related stress. In response, we just keep on pushing through, surviving on adrenaline. We overschedule ourselves; we drink another coffee; we respond to one more email. If we stay amped up all the time, we think, we’ll eventually be able to get things done. But all that does is burn us out, drain our productivity, and lead to ex...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness adrenaline Breathing coffee creativity Decision-making exhaustion Mindfulness-Training productivity relaxed state-of-mind Stress Stress Response workplace Source Type: blogs
Music therapy (MT) in the inpatient setting has demonstrated positive outcomes worldwide. There was no protocol to utilize MT at this organization. The purpose of this project was to incorporate and evaluate MT as an adjunct intervention to address pain and anxiety in adult surgical step-down patients. Evidence-based practice change using the 8A's method integrated individualized MT provided by a board-certified music therapist to hospitalized patients over a 3-month period. Training was provided to 35 nurses and unit-assigned social worker on the utilization of MT for patients exhibiting pain or anxiety symptoms. The clin...
Source: Critical Care Nursing Quarterly - Category: Nursing Tags: Original Articles Source Type: research
(Ohio State University) About one-third of patients newly diagnosed with the most common form of lung cancer have moderate to severe symptoms of depression, a new study suggests. For many of these patients -- particularly those with severe symptoms -- depression occurs in a toxic blend of high levels of anxiety, traumatic stress, impaired day-to-day functioning and significant pain and other physical symptoms, findings showed.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
ConclusionInterventional strategies, including group interventions, brief individual interventions, longitudinal counseling, and consideration of early amputation in selected populations have proved effective in reducing negative psychological sequelae of major orthopedic trauma. Further research that determines the effects of interventions in this population is needed.
Source: HSS Journal - Category: Orthopaedics Source Type: research
While opioids are often prescribed to treat people with trauma-related pain, a new UCLA-led study suggests doctors should use caution before prescribing the drug to those they believe may experience severe stress in the future, in order to reduce the risk the patient will develop PTSD.In the study, researchers administered doses of the opioid morphine to a group of 22 mice for one week, then gave the mice relatively strong foot shocks. After the morphine wore off, the mice were given mild electric foot shocks. These mice showed a substantially longer “freezing response” than a second, control group of 24 mice t...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Treating psychiatric patients for sleep disturbances can lead to improvements in their quality of life and mental health, but few mental health professionals receive thorough training on how best to assess common sleep complaints. So wrote John W. Winkelman, M.D., Ph.D., a professor of psychiatry at Harvard Medical School and chief of the Sleep Disorders Clinical Research Program at Massachusetts General Hospital, in anarticle inJAMA Psychiatry.“Sleep is a powerful biological drive but, paradoxically, is easily perturbed by a variety of processes. Psychiatric illnesses are one such influence, and … many psychi...
Source: Psychiatr News - Category: Psychiatry Tags: anticonvulsants antidepressants cbt-i cognitive-behavioral therapy hypnotics JAMA Psychiatry John W. Winkelman melatonin agonists orexin antagonists psychiatric illness sleep sleep problems Source Type: research
More News: Antidoxidants | Anxiety | Brain | Environmental Health | Neurology | Pain | Study