Involvement of E2f1 deficiency in salivary gland hypofunction: A review of studies of E2f1-deficient NOD/SCID mice

Conclusion In E2f1-deficient NOD/SCID mice, the number of duct cells increased while the number of acinar cells decreased. The water channel aquaporin 5, a marker of acinar cells, demonstrated diffuse localization, ubiquitination, and decreased expression in E2f1-deficient NOD/SCID mice. These events seem to trigger salivary gland hypofunction in E2f1-deficient NOD/SCID mice, which suggest that E2f1 is a key factor in the development of xerostomia.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research