Characterization of acute myeloid leukemia with del(9q) – impact of the genes in the minimally deleted region

Acute myeloid leukemia (AML)1 arises from clonal expansion of malignant hematopoietic precursor cells of the bone marrow. The broad variety of clinical features is the result of different alterations in multiple cellular pathways. This leads to a wide range of subgroups and different treatment options. Recent studies revealed distinct molecular subgroups of AML harboring single or combined somatic mutations [1]. The deletion of a portion of the long arm of chromosome 9, del(9q), is a recurring abnormality in malignant myeloid diseases reported in approximately 2% of AML cases [2].

Source: Leukemia Research - November 17, 2018 Category: Hematology Authors: Isabel S. Naarmann-de Vries, Yvonne Sackmann, Felicitas Klein, Antje Ostareck-Lederer, Dirk H. Ostareck, Edgar Jost, Gerhard Ehninger, Tim H. Br ümmendorf, Gernot Marx, Christoph Röllig, Christian Thiede, Martina Crysandt Tags: Research paper Source Type: research