[Brain stimulation for the selective treatment of schizophrenia symptom domains : Non-invasive and invasive concepts].

[Brain stimulation for the selective treatment of schizophrenia symptom domains : Non-invasive and invasive concepts].
Nervenarzt. 2018 Nov 14;:
Authors: Kinfe TM, Hurlemann R
Abstract
Given that one third of patients with schizophrenia (SZ) only show limited response to established treatments, alternative therapeutic strategies such as non-invasive/invasive brain stimulation approaches have emerged as an adjunctive treatment option for distinct SZ symptom domains (e.g. acoustic hallucinations, negative/positive symptoms and cognitive impairment). aking comparative interventional studies and standardized technical parameters into consideration, current meta-analyses indicate that adjunctive electroconvulsive therapy, repetitive transcranial magnetic stimulation and transcranial direct current stimulation have a positive effect. Invasivedeep brain stimulation and MR-guided ultrasound brain ablation procedures represent treatment modalities that are currently being clinically tested. Supplementary preinterventional investigation methods (e.g. electrophysiology, neuroimaging and molecular inflammatory profiling) have been recommended in order to identify symptom-tailored predictive measures for diagnosis and treatment.
PMID: 30430190 [PubMed - as supplied by publisher]

Source: Der Nervenarzt - November 14, 2018 Category: Neurology Authors: Kinfe TM, Hurlemann R Tags: Nervenarzt Source Type: research