Drug Withdrawal Inadvisable in'Recovered' Dilated Cardiomyopathy Drug Withdrawal Inadvisable in'Recovered' Dilated Cardiomyopathy

Withdrawal of heart failure drug therapy from patients deemed to have'recovered'from dilated cardiomyopathy resulted in a relapse rate of 40% in the TRED-HF study.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news

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AbstractBackgroundTachycardia-induced cardiomyopathy (TCM) has been known for decades as a  reversible form of non-ischemic cardiomyopathy. However, its mechanism and characteristics remain poorly understood.ObjectivesThis retrospective study investigated endomyocardial biopsy (EMB) samples from consecutive patients with TCM and compared them with samples from patients with dilated cardiomyopathy (DCM) and inflammatory cardiomyopathy (InCM).Materials and methodsA total of 684 patients (18  TCM, 170 DCM, 496 InCM) with recent-onset heart failure and reduced ejection fraction unrelated to valvular or ischemic heart...
Source: Herzschrittmachertherapie und Elektrophysiologie - Category: Cardiology Source Type: research
AimsThe prevalence and hospitalizations of patients with heart failure (HF) aged
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
We describe the case of an 18‐year‐old male patient, affected by DMD and in a wheelchair from the age of 11. He progressively developed dilated cardiomyopathy, and in 2016, at the age of 14 years, he underwent HeartWare LVAD implantation, as destination therapy, without post‐operative complications. He has been followed up for 47 consecutive months; and 30 months after LVAD implantation, he developed an infection of the exit site, treated by antibiotics and surgical toilette. Following this event, on the basis of patient's good general conditions and willingness, we started to consider heart transplant as a...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research
Conclusions: DCM and ICM are considered the most prevalent underlying diseases in heart transplant candidates. Ejection fraction reached normal ranges following transplant, which provides good quality of life. Low incidence of severe acute rejection demonstrates the effectiveness of our immunosuppressive therapy. In the cases of increased rejection, the patient's immunosuppressive regimen was re-assessed accordingly. PMID: 32728361 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
ABSTRACTAimsNon ‐sustained ventricular tachycardia (NSVT) occurs frequently in patients with dilated cardiomyopathy (DCM), especially in high‐risk patients. The role of rapid‐rate NSVT (RR‐NSVT) documented by an implantable cardioverter defibrillator (ICD) in DCM patients has not been fully explored. This s tudy aimed to determine the relationship between RR‐NSVT and the occurrence of ventricular tachyarrhythmias (VTAs) in DCM patients with ICD.MethodsFrom December 2000 to December 2017, 136 DCM patients received ICD or cardiac resynchronization therapy defibrillator (CRT ‐D) implantation for primary or seconda...
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ORIGINAL ‐ DEVICE Source Type: research
European Journal of Heart Failure, EarlyView.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Editorial Comment Source Type: research
AbstractAimsCurrently, the ejection fraction [left ventricular ejection fraction (LVEF)] is the main criterion used for implanting implantable cardioverter defibrillators (ICDs) for primary prevention. However, many of ICD receivers would not have an event and do not have any gains from the device. Consequently, improving the discrimination strategies is needed. Here, we aimed at assessing the role of global longitudinal strain (GLS) for such purpose.Methods and resultsSeventy ischaemic or dilated cardiomyopathy cases characterized by LVEF  ≤ 40% with a previously implanted ICD were enrolled. LVEF and GLS amou...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
This study enrolled 39 NIDCM patients, who underwent plasma amino acid (AA) analysis. The ratio of BCAAs to total AAs was calculated. All patients were divided into two groups at the median of BCAA/total AA ratio; high BCAA/total AA group (≥ 0.15, n = 20) and low BCAA/total AA group (
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
This study aimed to assess the ability of PAPi to stratify DCM patients without severe symptoms.Methods and Results:Between April 2000 and March 2018, a total of 162 DCM patients with stable symptoms were evaluated, including PAPi, and followed up for a median of 4.91 years. The mean age was 50.9±12.6 years and the mean LV ejection fraction (EF) was 30.5±8.3%. When divided into 2 groups based on median value of PAPi (low, L-PAPi [
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
(University of Calgary) An international study led by Dr. James White, a clinician and researcher at the University of Calgary finds magnetic resonance imaging can be used to predict major cardiac events for people diagnosed dilated cardiomyopathy. White's study confirms about 40 per cent of patients with DCM have scarring patterns on their heart muscle which can be seen with MRI. These patterns are associated with higher risk of future heart failure admissions, life-threatening heart rhythms and death.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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