Long –Standing evolution of paraneoplastic cerebellar degeneration in a diffuse large B-cell lymphoma

Paraneoplastic cerebellar degeneration (PCD) is characterized by pancerebellar ataxia with diplopia, nystagmus and dysarthria that might evolve subacutely or over months to years [1 –8]. Blurred vision and oscillopsia typically occur early in the disease, often preceding the manifestations of the primary malignancy [1–8]. Malignancies most commonly associated with PCD include gynecologic, breast, small cell lung cancers, Hodgkin's lymphoma [1–8]. The combination of tumour s and neurologic disability suggests the occurrence of effective antitumour autoimmunity, especially in cases with associated antibodies (anti-Yo and Ri, anti-Hu, anti-Tr and mGluR1) [1–8].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research