Targeting an Autocrine Regulatory Loop in Cancer Stem-Like Cells Impairs the Progression and Chemotherapy Resistance of Bladder Cancer.

CONCLUSIONS: OV6 could be a helpful indicator of disease progression and prognosis for BCa patients, and targeting the autocrine YAP/TEAD1/PDGF-BB/PDGFR loop might serve as a remedy for cis-platinum resistance in patients with advanced BCa.
PMID: 30397177 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - November 5, 2018 Category: Cancer & Oncology Authors: Wang KJ, Wang C, Dai LH, Yang J, Huang H, Ma X, Zhou Z, Yang ZY, Xu W, Hua MM, Lu X, Zeng S, Wang HQ, Zhang Z, Cheng YQ, Liu D, Tian QQ, Sun YH, Xu CL Tags: Clin Cancer Res Source Type: research