In Situ Gluten –Chitosan Interlocked Self‐Assembled Supramolecular Architecture Reduces T‐Cell‐Mediated Immune Response to Gluten in Celiac Disease

ConclusionOverall, the results demonstrate the potential of this research avenue to celiac disease is problematic, as the reorganization of gluten proteins to a novel supramolecular architecture shows a positive impact on known pathogenesis mechanisms of the disease. At present, the only therapy for celiac disease is adherence to a gluten ‐free diet. Here, it is shown that chitosan‐imposed gluten reorganization to an interlocked self‐assembled supramolecular architecture reduces gluten digestibility, R5‐reactivity, tissue transglutaminase deamidation activity, and its capacity to stimulate a T‐cell‐mediated immune respons e in celiac disease.

Source: Molecular Nutrition and Food Research - October 21, 2018 Category: Food Science Authors: Miguel Ribeiro, Stefania Picascia, Larbi Rhazi, Carmen Gianfrani, Jose Maria Carrillo, Marta Rodriguez ‐Quijano, Gérard Branlard, Fernando M. Nunes Tags: Research Article Source Type: research