Nanoparticle Eluting-Angioplasty Balloons to Treat Cardiovascular Diseases

Publication date: Available online 5 November 2018Source: International Journal of PharmaceuticsAuthor(s): Roshni Iyer, Aneetta E. Kuriakose, Serkan Yaman, Lee-Chun Su, Dingying Shan, Jian Yang, Jun Liao, Liping Tang, Subhash Banerjee, Hao Xu, Kytai T. NguyenAbstractNanoparticles (NPs) can be used to locally deliver anti-restenosis drugs when they are infused directly to the injured arteries after intervention procedures such as angioplasty. However, the efficacy of transferring NPs via infusion to the arterial wall is limited, at least partially, due to poor NP retention on the inner artery wall. To improve NP retention, angioplasty balloons coated with drug-loaded NPs were fabricated via either layer-by-layer (LbL) electrostatic coating or acrylic-based hydrogel (AAH) coating techniques. Three types of NPs, namely poly (lactide-co-glycolide) (PLGA), biodegradable photo-luminescent PLGA and urethane doped polyester were studied. The transfer efficacy of NPs from various coatings to the arterial wall were further evaluated to find the optimal coating conditions. The ex vivo NP transfer studies showed significantly more NPs being transferred to the rat arterial wall after the angioplasty procedure by the AAH coating (95% transfer efficiency) compared to that of the LbL technique (60%) and dip coating (20%) under flow conditions (10 dyn/cm2). Our results suggest that the AAH coating of drug-loaded NPs on the angioplasty balloon could potentially provide superior retention of dr...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research