Efficacy and safety of drug-eluting stent for the intracranial atherosclerotic disease: A systematic review and meta-analysis

Publication date: Available online 3 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Gengfan Ye, Xiaoliang Yin, Ximeng Yang, Junjie Wang, Peng Qi, Jun Lu, Lijun Wang, Daming WangAbstractDrug-eluting stent (DES) is a potential endovascular treatment for patients with symptomatic intracranial atherosclerotic disease (sICAD). However, evidence regarding the treatment of ICAD with DES is lacking. We systematically searched Pubmed, Embase, Cochrane database (before 2017-12-21) for literature reporting the application of DES in the treatment of sICAD. The main outcomes were as follows: the incidence of any stroke or death within 30 days (perioperative complications), ischemic stroke in the territory of the qualifying artery beyond 30 days (long-term complications), in-stent restenosis rate (ISR) and symptomatic ISR during follow-up. Those studies with mean stenosis rate greater than 70% and less than 70% were defined as severe and moderate stenosis group, respectively. The random effect model was used to pool the data. Of 518 articles, 13 studies were eligible and included in our analysis (N = 336 patients with 364 lesions). After the implantation of DES, perioperative complications (mortality = 0) occurred in 6.0% (95%CI 2.0%–11.9%), long-term complications occurred in 2.2% (95%CI 0.7%–4.5%), ISR rate was 4.1% (95%CI 1.6%–7.7%) and the symptomatic ISR rate was only 0.5% (95%CI 0–2.2%). In addition, subgroup analysis showed that the perioperative...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research