Super-resolution imaging reveals that loss of the C-terminus of connexin43 limits microtubule plus-end capture and NaV1.5 localization at the intercalated disc

Conclusions NaV1.5 and EB1 localization at the cell end is Cx43-dependent. Cx43 is part of a molecular complex that determines capture of the microtubule plus-end at the ID, facilitating cargo delivery. These observations link excitability and electrical coupling through a common molecular mechanism.

http://cardiovascres.oxfordjournals.org/cgi/content/short/104/2/371?rss=1

Source: Cardiovascular Research - October 31, 2014 Category: Cardiology Authors: Agullo-Pascual, E., Lin, X., Leo-Macias, A., Zhang, M., Liang, F.-X., Li, Z., Pfenniger, A., Lubkemeier, I., Keegan, S., Fenyo, D., Willecke, K., Rothenberg, E., Delmar, M. Tags: Ion channels and arrhythmias Source Type: research