Chitosan-based thermosensitive hydrogel for nasal delivery of exenatide: Effect of magnesium chloride

In this study, the effects of CaCl2 and MgCl2 within CS/GP hydrogel system on the nasal delivery of EXT were systematically studied in rats. Compared with CaCl2, MgCl2 enhanced stability of exenatide and prolonged gelation time of hydrogel at 37°C. Furthermore, CS/GP/MgCl2 hydrogel not only enhance more amount of exenatide transported across Calu-3 cell monolayers, but also significantly increased distribution of exenatide in targeting organs and bioavailability of exenatide in rats after nasal administration relative to CS/GP/CaCl2 hydrogel. Moreover, the exenatide hydrogel formulation treatment in high-fat-fed rats significantly decreased food intake and body weight relative to exenatide solution within ten days after nasal administration.
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research