Influence of polyvinyl chloride infusion extension tube on propofol injection pain: A randomised controlled study

BACKGROUNDPropofol injection pain is a common and unsolved anaesthesia problem. OBJECTIVESThe present study attempted to confirm that the plasticiser di(2-ethylhexyl) phthalate in polyvinyl chloride (PVC) infusion tubes may increase propofol injection pain by increasing the aqueous propofol concentration. DESIGNA randomised controlled study. SETTINGUniversity teaching hospital, 1 April to 25 June 2013. PATIENTSOne hundred patients scheduled for elective surgery were allocated randomly to the PVC or the control (C) group. The PVC group received a propofol (Diprivan) infusion via a 1-m PVC infusion extension tube, whereas group C received propofol injected directly through the port of the cannula. INTERVENTIONAfter the syringe was loaded with propofol, air was expelled from the tube and the syringe was left standing for 5 min; intravenous propofol 0.5 mg kg−1 was then injected either through the PVC tube or directly into the cannula. MAIN OUTCOME MEASUREA verbal rating scale was used to evaluate the propofol injection pain in both groups. Di(2-ethylhexyl) phthalate and aqueous propofol concentrations were also measured in samples of propofol after simulated injection. To investigate whether the increase in aqueous propofol concentration was caused by leached di(2-ethylhexyl) phthalate, the same amount of di(2-ethylhexyl) phthalate as that measured in the PVC group was added to the samples (group D). RESULTSThe incidences of pain in groups PVC and C were 88 and 46%, resp...
Source: European Journal of Anaesthesiology - Category: Anesthesiology Tags: Pharmacology Source Type: research