Loss of EMILIN-1 Enhances Arteriolar Myogenic Tone Through TGF- β (Transforming Growth Factor-β)-Dependent Transactivation of EGFR (Epidermal Growth Factor Receptor) and Is Relevant for Hypertension in Mice and Humans.

Conclusions- Taken together, our findings implicate an unexpected role of the TGF-β-EGFR pathway in hypertension with current translational perspectives. PMID: 30354220 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30354220?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 1, 2018 Category: Cardiology Authors: Carnevale D, Facchinello N, Iodice D, Bizzotto D, Perrotta M, De Stefani D, Pallante F, Carnevale L, Ricciardi F, Cifelli G, Da Ros F, Casaburo M, Fardella S, Bonaldo P, Innocenzi G, Rizzuto R, Braghetta P, Lembo G, Bressan GM Tags: Arterioscler Thromb Vasc Biol Source Type: research