High Glucose-Mediated Cytokine Regulation in Gingival Fibroblasts and THP-1 Macrophage: a Possible Mechanism of Severe Periodontitis with Diabetes

Conclusion: Diabetic conditions such as HG induce IL-1 β and sIL-6R production from macrophages in inflammatory periodontal tissues and may exacerbate the periodontitis synergistically via MMP-1 production from HGFs.Cell Physiol Biochem 2018;50:973 –986
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research