Hydroxyapatite nanorods loaded with parathyroid hormone (PTH) synergistically enhance the net formative effect of PTH anabolic therapy

This study focuses on synthesis, characterization and evaluation of in vitro and in vivo efficacy of PTH (1–34) adsorbed hydroxyapatite nanocarrier for synergistic enhancement in the anabolic activity of PTH for bone regeneration. The negative zeta potential of this nanocarrier facilitated its affinity to the Ca2+ rich bone tissue and solubilization at low pH enhanced specific delivery of PTH to the resorption pits in osteoporotic bone. In this process, PTH retained its anabolic effect and at the same time an increase in bone mineral content indicated enhancement of the net formative effect of the PTH anabolic therapy.Graphical AbstractSchematic illustration of the synthesis of PTH loaded hydroxyapatite nanocarrier for targeted delivery to osteoporotic bone.Hydroxyapatite nanorods (nHAp), subjected to physical adsorption of parathyroid hormone (PTH (1–34)), were synthesized to carry PTH to the bone and specifically deliver it to the regions with high osteoclast activity. Notably, the nHAp-PTH (1–34) nanocarrier enhances the in vitro osteogenesis as well as bone regeneration in vivo studies.
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research