Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish.

This study indicates that the single S-S bond folded PpVα peptide arises as a new structural template to develop sodium channel blockers and provides an insight on the peptide discovery from cnidarian transcriptome to potentially manage epilepsy and neurodegenerative disorders. PMID: 30334080 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30334080?dopt=Abstract

Source: Archives of Toxicology - October 17, 2018 Category: Toxicology Authors: Liao Q, Li S, Siu SWI, Morlighem JRL, Wong CTT, Wang X, Rádis-Baptista G, Lee SM Tags: Arch Toxicol Source Type: research