Inhibition of miR-128 Abates A β-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells.

CONCLUSION: MiR-128 inhibitor decreased Aβ-mediated cytotoxicity by upregulating PPAR-γ via inactivation of NF-κB in MCN and N2a cells, providing a new potential target in AD treatment.
PMID: 30328325 [PubMed - in process]

Source: Yonsei Medical Journal - October 18, 2018 Category: Universities & Medical Training Authors: Geng L, Zhang T, Liu W, Chen Y Tags: Yonsei Med J Source Type: research