PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition.

CONCLUSIONS: CircPRMT5 exerts critical roles in promoting UCB cells EMT and/or aggressiveness and is a prognostic biomarker of the disease, suggesting that circPRMT5 may serve as an exploitable therapeutic target for UCB patients.
PMID: 30305293 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 10, 2018 Category: Cancer & Oncology Authors: Chen X, Chen R, Wei WS, Li Y, Feng ZH, Tan L, Chen JW, Yuan G, Chen S, Guo SJ, Xiao K, Liu ZW, Luo JH, Zhou FJ, Xie D Tags: Clin Cancer Res Source Type: research