In Chronic Kidney Disease, Serum α-Klotho is Related to Serum Bicarbonate and Proteinuria

Klotho is an “aging-suppressor” gene and encodes a single-pass transmembrane protein predominantly expressed in renal tubules. Whether chronic kidney disease (CKD) affects serum Klotho is poorly documented. We aimed to measure the relationship of serum α-Klotho with renal function, acid–base status, bone biomarkers, and proteinuria in CKD patients.

Source: Journal of Renal Nutrition - September 4, 2014 Category: Urology & Nephrology Authors: Valerie Hage, Solenne Pelletier, Laurence Dubourg, Jocelyne Drai, Charlotte Cuerq, Sandrine Lemoine, Aoumeur Hadj-Aissa, Maurice Laville, Denis Fouque Tags: Original Research Source Type: research