Initial Fluid Therapy in Pediatric Diabetic Ketoacidosis: A comparison of Hypertonic Saline Solution and Normal Saline Solution.

CONCLUSIONS: Both 0.9% saline and 3% saline were equally effective as initial fluid in children with DKA with respect to hemodynamic improvement, the resolution of acidosis and the correction of hyperglycemia, but the use of 3% saline solution did not preclude the development of cerebral edema and has the potential to cause hypernatremia, hyperchloremia and hyperchloremic metabolic acidosis.
PMID: 30300426 [PubMed - in process]

Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Shafi O, Kumar V Tags: Pediatr Endocrinol Diabetes Metab Source Type: research