Potential epigenetic therapeutics for atherosclerosis treatment

Notwithstanding the intense efforts into understanding and preventing cardiovascular disease (CVD), its complex pathology remains the leading cause of mortality worldwide. The pivotal role of epigenetic changes in the control of gene expression has been profiled in several diseases, such as cancer and inflammatory disorders. In the last decade, increasing evidence has also linked aberrant epigenetic modulation as a contributor to CVD development. Differential profiles of DNA methylation, histone methylation and acetylation have consistently been observed in tissues and cells (comprising the aortic lesions, vascular endothelium and monocytes) from patients with CVD.

Source: Atherosclerosis - October 8, 2018 Category: Cardiology Authors: Ioana Nicorescu, Geesje M. Dallinga, Menno P.J. de Winther, Erik S.G. Stroes, Mahnoush Bahjat Tags: Review article Source Type: research