Changes in levels of cortical metabotropic glutamate 2 receptors with gender and suicide but not psychiatric diagnoses

We have reported that, compared to controls, there are lower levels of [3H]LY341495 binding in Brodmann's area (BA) 24, but not BA 17 or 46, from subjects with major depressive disorders (MDD) (McOmish et al., 2016). [3H]LY341495 binding was not altered in those three cortical regions from subjects with bipolar disorders (BD) or schizophrenia. As [3H]LY341495 binds to the mammalian metabotropic glutamate receptors (GRM) 2 and 3 (Johnson et al., 1999; Wright et al., 2001), our data is consistent with the notion that there is a decrease in the total number of GRM2 plus GRM3 in BA 24 from subjects with MDD.

Source: Journal of Affective Disorders - October 5, 2018 Category: Neurology Authors: Brian Dean, Clare Duncan, Andrew Gibbons Source Type: research