Chronic kidney disease correlates with increased risk of pulmonary tuberculosis before initiating renal replacement therapy: A cohort study in Taiwan

This study aimed to assess the association between chronic kidney disease (CKD) and the risk of pulmonary tuberculosis (TB) before initiating renal replacement therapy (RRT) in Taiwan. Total 16,052 subjects newly diagnosed with CKD between 2000 and 2012 were included in the CKD group, and 31,949 randomly selected subjects who did not have CKD formed the non-CKD group. Subjects with a history of pulmonary TB or RRT, including dialysis and renal transplantation, before the index date were excluded. We determined the incidence of pulmonary TB at the end of 2013. A multivariable Cox proportional hazards regression model was used to assess the hazard ratio (HR) and 95% confidence interval (CI) for the risk of developing pulmonary TB associated with CKD. The overall incidence of pulmonary TB was 1.47-fold greater in the CKD group compared to that in the non-CKD group (4.94 vs 3.35 per 1000 person-years, 95% CI 1.39, 1.56). Multivariable Cox proportional hazards regression analysis showed that the adjusted HR of pulmonary TB was 1.45-fold higher in the CKD group (95% CI 1.27, 1.64) than in the non-CKD group. Male sex (adjusted HR 2.04), age (increase per one year, adjusted HR 1.05), chronic obstructive pulmonary disease (adjusted HR 1.54), and diabetes mellitus (adjusted HR 1.34) were also associated with pulmonary TB. CKD is associated with an increased risk of developing pulmonary TB before the initiation of RRT.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Related Links:

[Vanguard] Abuja -The Federal Government said it had concluded arrangements to convert tuberculosis' diagnostic machines in the country coronavirus' detection machines.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
[The Herald] Government is working on utilising tuberculosis and HIV testing machines to run Covid-19 tests.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
[Daily Trust] Nigeria is looking to convert more than 300 GeneXpert machines used to tuberculosis diagnosis for use in coronavirus testing in three weeks at most, health minister Osagie Ehanire said on Tuesday.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Publication date: Available online 30 March 2020Source: Journal of Clinical NeuroscienceAuthor(s): Cheng-Yu Tsai, Tai-Hsin Tsai, Yu-Feng Su
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Contributors : Elizabeth Ostrander ; Grant A ChallenSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Mus musculusEpigenetic modifying enzymes DNMT3A and TET2 are recurrently mutated in hematological disorders despite possessing opposing biochemical functions in the DNA methylation processes. Using conditional ablation, we show these contrasting genotypes result in different functional effects in hematopoietic stem cells (HSCs). Loss of Dnmt3a bestows enhanced self-renewal on HSCs in serial, competitive repopulation assays while Tet...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Mus musculus Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
More News: Chronic Kidney Disease | Chronic Obstructive Pulmonary | Diabetes | Diabetes Mellitus | Dialysis | Endocrinology | Internal Medicine | Kidney Transplant | Kidney Transplantation | Study | Taiwan Health | Transplants | Tuberculosis | Urology & Nephrology