Crosstalk in Cancer Resistance and Metastasis

Prolonged exposure to chemotherapeutic drugs can result in the development of drug resistance in tumor cells leading to clinical failure of the chemotherapy regime (Ghandadi et al., 2016a). Drug resistance may be intrinsic and present before exposure to the medications (Ghandadi et al., 2016b). However, research studies show that in tumor cells acquired drug resistance is more common than inherent drug resistance (Wu et al., 2014). Many studies have reported that drug resistance is accompanied by upregulation of Epithelial Mesenchymal Transition (EMT) associated proteins expression leading to enhanced migration and metastasis of tumor cells (I şeri et al., 2011; Sarrió et al., 2008; Zhang et al., 2014).
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research