Single Agent Treats Two Cancers With Same Genetic Cause

Pembrolizumab treated colon cancer, intrahepatic cholangiocarcinoma in patient with Lynch syndrome
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pathology, Pharmacy, Journal, Source Type: news

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Date: Wednesday, 07 17, 2019; Speaker: Mary Kearney, PhD, Head, Translational Research Unite, HIV Dynamics and Replication Program, Center, National Cancer Institute;
Source: NIH Calendar of Events - Category: American Health Source Type: events
In this study, we constructed a dual function nanosystem, copper sulfide nanoplatform loaded with the chemotherapeutic drug docetaxel wrapped by a conjugated polymer-peptide for targeted chemo-phototherapy. The nanoconstruct has been successfully designed with a size of 186.1 ± 5.2 nm, a polydispersity index of 0.18 ± 0.01, and zeta potential of −16.4 ± 0.1 mV. The enhanced uptake and near-infrared-responsive behavior of the nanosystem resulted in efficient drug release, photothermal ablation, effective cytotoxic activity, and potentiated reactive oxygen sp...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
We examined the U.S. thoracic surgery workforce using the 2010 and 2014 Area Health Resource Files. We calculated the density of thoracic surgeons per 100,000 persons for each year at the state and county level. We performed descriptive statistics and developed maps highlighting changes over time and geographic regions.ResultsDespite an overall increase in thoracic surgeons from 2010 to 2014, we observed declining density nationwide (1.5% change) and in sparsely populated states. The difference in thoracic surgeon density widened slightly between 2010 from 0.80 per 100,000 compared to 0.84 per 100,000 in 2014 in all rural ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 24 June 2019Source: Biosensors and BioelectronicsAuthor(s): Diaa I. Osman, Said M. El-Sheikh, Sheta M. Sheta, Omnia I. Ali, Aliaa M. Salem, Wafaa Gh Shousha, Sherif F. EL-Khamisy, Sherif M. ShawkyAbstractDevelopment of ultra-sensitive, high specific and cost-effective nucleic acids (NAs) biosensors is critical for early diagnosis of cancer, genetic diseases and follows up response to treatment. Metal-organic frameworks (MOFs) as sensing materials underwent significant development in recent years due to their unique merits, such as structural diversity, tunable pore scale, large surface ar...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 22 June 2019Source: Biosensors and BioelectronicsAuthor(s): Mohsen Mohammadniaei, Anna Guo, Sachin Ganpat Chavan, Aneesh Koyappayil, Seong-Eun Kim, Hyun Jin Yoo, Junhong Min, Min-Ho LeeAbstractDevelopment of a very sensitive biosensor is accompanied with an inevitable shrinkage in the linear detection range. Here, we developed an electrochemical biosensor with a novel methodology to detect microRNA-21 (miR21) at an ultralow level and broad linear detection range. A three-way junction RNA structure was designed harboring (i) a methylene blue (MB)-modified hairpin structure at its one leg t...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
We examined whether knowing someone who has an advanced breast cancer would influence knowledge, attitudes, beliefs, and practices of self and clinical breast-examination. We conducted a descriptive cross-sectional survey of 67 women, who were purposively sampled based on relation, through patients receiving palliative care services at a tertiary healthcare facility. Participants were non-blood relation of the patients and hence, referred to as patients’ micro-community. Data were collected from January to June 2018, using an adapted and adopted questionnaire and analyzed in R software version Statistical si...
Source: International Journal of Africa Nursing Sciences - Category: African Health Source Type: research
Publication date: Available online 23 June 2019Source: Redox BiologyAuthor(s): Diego G. Ogando, Moonjung Choi, Rajalekshmy Shyam, Shimin Li, Joseph A. BonannoAbstractSLC4A11 is a NH3 sensitive membrane transporter with H+ channel-like properties that facilitates Glutamine catabolism in Human and Mouse corneal endothelium (CE). Loss of SLC4A11 activity induces oxidative stress and cell death, resulting in Congenital Hereditary Endothelial Dystrophy (CHED) with corneal edema and vision loss. However, the mechanism by which SLC4A11 prevents ROS production and protects CE is unknown. Here we demonstrate that SLC4A11 is localiz...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 22 June 2019Source: Chemico-Biological InteractionsAuthor(s): Chandra Kishore, Sandhya Sundaram, Devarajan KarunagaranAbstractTumor recurrence and metastasis decrease the survival rate of colorectal cancer (CRC) patients. Menadione reduces the numbers and incidences of 1,2-dimethylhydrazine induced colon tumors in mouse but the mechanism of anticancer activity of menadione in colorectal cancer is not very clear. Since Wnt signaling is constitutively active in CRC and it aggravates the epithelial mesenchymal transition (EMT), the regulation of EMT and Wnt signaling by menadione (vitamin K3...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ01902B, PaperAman Chandra Kaushik, Ajay Kumar, Chun-Yen Yu, Shiao-Wei Kuo, Shih-Shin Liang, Satya P. Singh, Xiangeng Wang, Yan-Jing Wang, Chung-Kun Yen, Xiaofeng Dai, Dongqing Wei, Cheng-Tang Pan, Yow-Ling Shiue Researchers promoted polymer microspheres in medical engineering and biotechnology such as embedded drug delivery of poly lactic acid microspheres. Polycaprolactone (PCL) is kind of semi-crystalline polymer which was utilized in... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Lab Chip, 2019, Advance Article DOI: 10.1039/C8LC01359D, CommunicationYuan Wan, Mackenzie Maurer, Hong-Zhang He, Yi-Qiu Xia, Si-Jie Hao, Wen-Long Zhang, Nelson S. Yee, Si-Yang Zheng Nanoscale extracellular vesicles (nEVs) have recently demonstrated potential value in cancer diagnostics and treatment monitoring, but translation has been limited by technical challenges in nEV isolation. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
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