Childhood maltreatment moderates the influence of genetic load for obesity on reward related brain structure and function in major depression

Obesity is a highly prevalent comorbidity of affective disorders that has been shown to predict unfavorable outcomes in major depressive disorder (MDD) patients (de Wit et al., 2010; Kloiber et al., 2007; Luppino et al., 2010; Opel et al., 2015b; World Health Organization, 2014). In turn, findings indicating that both maternal depression and family history of obesity might increase the risk of non-response to weight-regulating interventions further corroborate the notion of a reciprocal link between obesity and depression and point to the relevance of shared genetic factors in the etiology of both conditions (Epstein et al., 1994; Pott et al., 2009).

Source: Psychoneuroendocrinology - September 21, 2018 Category: Psychiatry Authors: Nils Opel, Ronny Redlich, Jonathan Repple, Claas Kaehler, Dominik Grotegerd, Katharina Dohm, Dario Zaremba, Janik Goltermann, Lavinia-Alexandra M. Steinmann, Rahel Krugh öfer, Elisabeth J. Leehr, Joscha Böhnlein, Katharina Förster, Christian Bürger, S Source Type: research