Evaluation of the Association between Lithium Treatment and GSK3 β Polymorphism in Bipolar Disorder Patients.

CONCLUSION: The specific GSK-3β polymorphism that associated with lithium-response in our study may help to predict lithium responses and to develop individualized treatment. We presume that our pharmacogenomic findings may also provide important contributions to the clinical practice in regard to future evaluation of the treatment adherence and side effects. To obtain these goals, further genome-wide scanning studies conducted on larger sample cohorts are required. PMID: 30215834 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research

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Publication date: Available online 18 October 2019Source: NeuroImage: ClinicalAuthor(s): Sheri L. Johnson, Hershel Mehta, Terence A. Ketter, Ian H. Gotlib, Brian KnutsonAbstractAlthough behavioral sensitivity to reward predicts the onset and course of mania in bipolar disorder, the evidence for neural abnormalities in reward processing in bipolar disorder is mixed. To probe neural responsiveness to anticipated and received rewards in the context of bipolar disorder, we scanned individuals with remitted bipolar I disorder (n=24) and well-matched controls (n=24; matched for age and gender) using Functional Magnetic Resonance...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 14 October 2019Source: Microchemical JournalAuthor(s): Nada S. Abdelwahab, Amal B. Ahmed, Mahmoud A. Omar, Sayed M. Derayea, Maha M. AbdelrahmanABSTRACTNewly established green TLC-densitometric and RP-HPLC methods were developed and validated for simultaneous determination of quetiapine (QUT) (an antipsychotic drug) and the co-administrated drug, paroxetine (PAR) (an antidepressant drug). Both drugs are widely prescribed for treatment of bipolar depression. The proposed TLC-densitometric method was based on separation of the studied components and the internal standard (vincamine (VINC)) ...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: February 2020Source: Materials Science in Semiconductor Processing, Volume 106Author(s): V.L. Patil, Aditya A. Patil, S.V. Patil, N.A. Khairnar, N.L. Tarwal, S.A. Vanalakar, R.N. Bulakhe, Insik In, P.S. Patil, T.D. DongaleAbstractThe memristive devices are getting a lot of interest in recent years due to its applications in the field of resistive memory and brain-inspired computing. In the present work, we have developed a ZnO memristive device using the reflux method. We have demonstrated non-volatile memory properties and mimicked the basic synaptic properties of using Al/ZnO/FTO thin film device. The s...
Source: Materials Science in Semiconductor Processing - Category: Materials Science Source Type: research
This study was conducted at Department of Psychiatry, AIIMS, New Delhi with an aim to assess the self-reported medication adherence and its correlates among a naturalistic, lithium-maintained cohort (n = 76) with bipolar disorder. Subjects were included if they were on lithium therapy ≥1 year, met DSM-5 diagnosis of bipolar disorder and were in clinical remission (≥1 month). Besides sociodemographic and clinical performa, participants were assessed on medication adherence rating scale (MARS), lithium questionnaire for knowledge and lithium attitude questionnaire (LAQ). RESULTS: Mean age was 35.7&thi...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
nn W Abstract The Scanning Bipolar Electrochemical Microscope (SBECM) allows precise positioning of an electrochemical micro-probe serving as bipolar electrode that can be wirelessly interrogated by coupling the electrochemical detection reaction with an electrochemiluminescent reporting process. As a result, the spatially heterogeneous concentrations of an analyte of interest can be converted in real time into a map of sample reactivity. However, this can only be achieved upon optimization of the analytical performance ensuring adequate sensitivity. Here, we present the evaluation and optimized operation of the S...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
The objective of this study is to improve the corrosion resistance of nickel bipolar plate by means of conductive polymer coating. Typically, polypyrrole film has been electrodeposited using chronopotentiometric technique at different current densities in aqueous sodium saccharin medium. The electrochemical behaviour of nickel in the presence of sodium saccharinate solution in the absence and the presence of the pyrrole monomer were investigated using cyclic voltammetry. Characterization of the polypyrrole coating was carried out using x-ray photoelectrons (XPS) and scanning electron microscopy (SEM). Corrosion behavior of...
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: October 2019Source: Epilepsy &Behavior, Volume 99Author(s): Ravindra Arya, Brian Ervin, Jonathan Dudley, Jason Buroker, Leonid Rozhkov, Craig Scholle, Paul S. Horn, Jennifer Vannest, Anna W. Byars, James L. Leach, Francesco T. Mangano, Hansel M. Greiner, Katherine D. Holland, Tracy A. GlauserAbstractObjectiveWe prospectively validated stereo-electroencephalography (EEG) electrical stimulation mapping (ESM) of language against a reference standard of meta-analytic functional magnetic resonance imaging (fMRI) framework (Neurosynth).MethodsLanguage ESM was performed using 50 Hz, biphasic, bipolar, stim...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Abstract OBJECTIVE: We prospectively validated stereo-electroencephalography (EEG) electrical stimulation mapping (ESM) of language against a reference standard of meta-analytic functional magnetic resonance imaging (fMRI) framework (Neurosynth). METHODS: Language ESM was performed using 50 Hz, biphasic, bipolar, stimulation at 1-8 mA, with a picture naming task. Electrode contacts (ECs) were scored as ESM+ if ESM interfered with speech/language function. For each patient, presurgical MRI was transformed to a standard space and coregistered with computed tomographic (CT) scan to obtain EC locations. After...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Conclusion We recommend suture for hemostasis during laparoscopic cystectomy.Resumo Objetivo O objetivo desta revis ão foi comparar o impacto dos diferentes métodos hemostáticos na reserva ovariana durante a ooforoplastia laparoscópica. Fontes de Dados Os estudos foram identificados através da pesquisa de bases de dados eletrônicas (MEDLINE, Embase, Cochrane, LILACS) e listas de referência de artigos. S eleção dos estudos Selecionamos ensaios clínicos que avaliaram a influência das técnicas hemostáticas na reserva ovariana em pacientes ...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
ConclusionSG leaks can add long-term morbidity. Stent can be used successfully to treat SG leak if used judiciously. There should be low threshold for investigating patients with EWL of>  100% for anatomical complications like stricture, fistula or kink in the gastric sleeve. We wanted to make the bariatric fraternity aware of a rare late (>  12 weeks) complication of gastro-colic fistula after successfully treated SG leak. Limited literature is published about this rare complication and its management which ranges from conservative management to stent placement to surgical intervention (Asian Jour...
Source: Obesity Surgery - Category: Surgery Source Type: research
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