Low Dose Stingless Bee Honey Increases Viability of Human Dermal Fibroblasts That Could Potentially Promote Wound Healing

This study seeks to evaluate the effect of freeze-dried stingless bee honey on the cell viability and proliferative capacity of dermal fibroblast. Dermal fibroblast viability and proliferation will be evaluated via MTT assay, microscopic evaluation and cell cycle analysis. Short-term exposure of dermal fibroblasts to different honey doses revealed a multimodal pattern of increase in cell viability at the honey dose of 0.024, 200, and 6400 µg/ml. Treatment of the selected honey dose to dermal fibroblast proves to be non-toxic under microscopic evaluation and MTT assay. The selected dose of honey improves proliferation and did not alter normal cell cycle progression in dermal fibroblast. The positive effect that honey has on the cell viability and proliferation of dermal fibroblast suggested the capability of stingless bee honey to improve wound healing.
Source: Wound Medicine - Category: General Medicine Source Type: research