Gender differences in the association of syndecan-4 with myocardial infarction. The population-based Troms ø Study

Cardiovascular disease is a common cause of morbidity and mortality, with gender differences in pathophysiology. The endothelial glycocalyx maintains vascular integrity, and glycocalyx shedding reflects endothelial dysfunction and early atherosclerosis. Syndecan-1 and -4 are components of the glycocalyx, and increased serum levels indicate glycocalyx damage. We hypothesised that increased serum syndecan-1 and -4 were independently associated with myocardial infarction (MI), ischaemic stroke and all-cause mortality in men and women from a general population.

Source: Atherosclerosis - September 14, 2018 Category: Cardiology Authors: Marit D. Solbu, Svein O. Kolset, Trond G. Jenssen, Tom Wilsgaard, Maja-Lisa L øchen, Ellisiv B. Mathiesen, Toralf Melsom, Bjørn O. Eriksen, Trine M. Reine Source Type: research