Race, Sex, Age, and Regional Differences in the Association of Obstructive Sleep Apnea With Atrial Fibrillation: Reasons for Geographic and Racial Differences in Stroke Study
Study Objectives:To examine the cross-sectional association between obstructive sleep apnea (OSA) risk and atrial fibrillation (AF) in the REasons for Geographic And Racial Differences in Stroke (REGARDS), a cohort of black and white adults.Methods:Using REGARDS data from subjects recruited between 2003–2007, we assessed 20,351 participants for OSA status. High OSA risk was determined if the participant met at least two criteria from the Berlin Sleep Questionnaire (persistent snoring, frequent sleepiness, high blood pressure, or obesity). AF was defined as a self-reported history of a previous physician diagnosis or presence of AF on electrocardiogram. Logistic regression was used to determine odds ratio and 95% confidence interval for the association between OSA status and AF with subgroup analysis to examine effect modification by age, race, sex, and geographical region.Results:The prevalence of AF was 7% (n = 1,079/14,992) and 9% (n = 482/5,359) in participants at low and high risk of OSA, respectively (P
Authors: Finley JR, Wixted JT, Roediger HL Abstract Recent research in the eyewitness identification literature has investigated whether simultaneous or sequential lineups yield better discriminability. In standard eyewitness identification experiments, subjects view a mock-crime video and then are tested only once, requiring large samples for adequate power. However, there is no reason why theories of simultaneous versus sequential lineup performance cannot be tested using more traditional recognition memory tasks. In two experiments, subjects studied DRM (Deese-Roediger-McDermott) word lists (e.g., bed, rest, tir...
Contributors : Ashley McDonough ; Richard V Lee ; Shahani Noor ; Chungeun Lee ; Thu Le ; Michael Iorga ; Jessica L Phillips ; Sean Murphy ; Thomas M öller ; Jonathan R WeinsteinSeries Type : Expression profiling by arrayOrganism : Mus musculusStroke is the fifth leading cause of death in the United States and is a leading cause of serious long-term disability worldwide. Innate immune responses are critical in stroke pathophysiology, and microglia are key cellular effectors in the CNS response to ischemia/reperfusion. Using a transcriptional analysis approach, we identified a robust interferon (IFN)-stimulated gene res...
Contributors : Bing Han ; Honghong YaoSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Mus musculusAstrocyte activation is involved in the context of stroke. Our study provides a potential new therapeutic strategy to astrocyte activation in the context of stroke.
Contributors : Lucas C Pantaleao ; Susan E Ozanne ; Ania WilczynskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity during pregnancy is associated with fetal growth restriction in the offspring. We used RNA next generation sequencing analysis (HiSeq2000) to have a snapshot of the placenta transcriptome at embryonic day 19 to examine whether mice exposed to maternal obesity had significant changes in their transcriptome which may lead to growth restriction in the fetus.
Contributors : David Milan ; Ling XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe aim of this study is to perform transcriptome analysis on mouse left atrium tissue after long-term ibrutinib treatment or cardiac CSK knockout, in order to compared the enriched gene clusters.
The 2020 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline on the Evaluation and Management of Candidates for Kidney Transplantation is intended to assist health care professionals worldwide who evaluate and manage potential candidates for deceased or living donor kidney transplantation. This guideline addresses general candidacy issues such as access to transplantation, patient demographic and health status factors, immunological and psychosocial assessment. The roles of various risk factors and comorbid conditions governing an individual’s suitability for transplantation such as adherenc...
Conclusions. Seven years following PFT, the patient gained limb strength with a functional elbow and wrist, although with diminished digital dexterity and sensation. Based on data presented by other programs and our own experience, PFT is indicated for select patients.
Publication date: Available online 31 March 2020Source: Life SciencesAuthor(s): Mohamed A. Fouda, Korin E. Leffler, Abdel A. Abdel-Rahman