Age- and Bodyweight-dependent Allometric Exponent Model for Scaling Clearance and Maintenance Dose of Theophylline From Neonates to Adults

The objective of this study is to develop and evaluate single-exponent, bodyweight-dependent allometric exponent (BDE), age-dependent exponent (ADE), and segmented regression models for predicting clearance and maintenance dose of theophylline. Methods: The BDE model was described by the following equation: JOURNAL/thdm/04.02/00007691-201810000-00014/math_14MM1/v/2018-09-13T063150Z/r/image-tiff , where L × BW−M defines the BDE for clearance. The coefficient and the exponents L and M were estimated. The ADE model consisted of several empirical exponents based on age and ranged from 0.75 (children>5 years and adults) to 1.2 (premature neonates). Data for model development and validation were based on 52 subjects each. Results: All structural and statistical parameters were estimated with acceptable precision for single-exponent and BDE models (
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research