Child cancer patients get access to personalised therapy
England first country in Europe to benefit from deal Related items fromOnMedica Higher heart risk for survivors of childhood cancer One in 10 children in phase I cancer trials respond to drugs UK slower to diagnose child cancer than Germany Child cancer drug approved for NHS use Infertility much more likely after childhood cancer
In a large Australian study, researchers found that baby boys born with undescended testes had a higher risk of health problems like infertility and cancer, especially if corrective surgery was delayed.
The purpose of this study was to evaluate the effectiveness of a personalized educational intervention to increase adolescent and young adult (AYA) cancer survivors ’ knowledge of their risk for infertility and to determine their preferences for further education.
Small higher risk of non-invasive breast and ovarian tumours may not be due to treatment Related items fromOnMedica Only a third of women with regular bloating would see their GP Infertility much more likely after childhood cancer Unprotected sex among British teens – soars Experts call for wider HPV vaccination Use of contraceptive pill may lead to longer life
Publication date: April 2018Source: Best Practice &Research Clinical Obstetrics &Gynaecology, Volume 48Author(s): Gabriela N. Algarroba, Joseph S. Sanfilippo, Hanna Valli-PulaskiAbstractThe 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all patie...
Many survivors of childhood cancer will experience premature gonadal insufficiency or infertility as a consequence of their medical treatments. Ovarian tissue cryopreservation (OTC) remains an experimental means of fertility preservation with few reports focused on the surgical technique and postoperative outcomes for OTC in children.
ConclusionAlthough this population of women has above average knowledge scores, they still demonstrated a desire for more information on reproduction after cancer therapy. While PedsQL scores fell within a normal range, survivors report infertility would cause negative emotions.Implication for cancer survivorsThis information can be used refine educational programs within survivorship clinics to improve knowledge of post-treatment reproductive health.
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AbstractAdult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby causing a gr...
Authors: Gravholt CH, Chang S, Wallentin M, Fedder J, Moore P, Skakkebæk A Abstract Although first identified over 70 years ago, Klinefelter syndrome (KS) continue to pose significant diagnostic challenges, as many patients are still misdiagnosed, or remain undiagnosed. In fact, as few as 25% of KS patients are accurately diagnosed, and most of these diagnoses are not made until adulthood. Classic characteristics of KS include small testes, infertility, hypergonadothropic hypogonadism, and cognitive impairment. However, the pathophysiology behind KS is not well understood, although genetic effects are also th...