Child cancer patients get access to personalised therapy
England first country in Europe to benefit from deal Related items fromOnMedica Higher heart risk for survivors of childhood cancer One in 10 children in phase I cancer trials respond to drugs UK slower to diagnose child cancer than Germany Child cancer drug approved for NHS use Infertility much more likely after childhood cancer
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
(University of Michigan) Leukemia treatments often leave girls infertile, but a procedure developed by researchers at the University of Michigan working with mice is a step toward restoring their ability to be biological mothers.
Children born through IVF have slight increased risk of certain childhood cancers during first decade of life, study finds Related items fromOnMedica Infertility much more likely after childhood cancer Higher heart risk for survivors of childhood cancer One in 10 children in phase I cancer trials respond to drugs Foetal alcohol syndrome must be better recognised Review reveals young cancer patients are put at risk
ConclusionsPerinatal and early-life risk factors, and specifically indicators of brain trauma, exposure to toxic agents and immune system maturation, might be involved in the pathogenesis of childhood brain tumors. Larger studies should aim to replicate our findings and examine associations with tumor subtypes.
Abstract A balanced Robertsonian translocation results from fusion of two acrocentric chromosomes. Carriers are phenotypically normal, and are often diagnosed because of recurrent miscarriages, infertility or aneuploid offspring. Mortality and site-specific cancer risks in carriers have not been prospectively investigated. We followed 1987 carriers diagnosed in Great Britain for deaths and cancer risk, over an average of 24.1 years. Standardised mortality (SMR) and incidence (SIR) ratios were calculated comparing the number of observed events against population rates. Overall mortality was raised for carriers diagnosed aged
AbstractChemotherapy-induced gonadal dysfunction resulting in transient or persistent infertility depends on the type of drugs and cumulative dose, and it is an important long-term complication, especially for adolescent and young adult (AYA) cancer patients. Due to its importance, a clinical practice guideline for fertility preservation in childhood and AYA cancer patients was published by the Japan Society of Clinical Oncology (JSCO) in 2017. Although the precise mechanisms remain unclear, several studies reported that the cancer itself, not the cancer treatment, adversely affected semen quality. It is reported that that...
Young boys are often left infertile after childhood cancer treatment, with no way of preserving their sperm. Now, new research might allow them to father children.
Researchers have figured out how to grow human stem cells to help children treated for cancer who become infertile later in life.
In a large Australian study, researchers found that baby boys born with undescended testes had a higher risk of health problems like infertility and cancer, especially if corrective surgery was delayed.