Efficacy of Antibiotic Prophylaxis against ventilator-associated pneumonia

Publication date: Available online 1 September 2018Source: Journal of Hospital InfectionAuthor(s): Nasrinsadat Mirtalaei, Aliasghar Farazi, Mohsen Ebrahimi Monfared, Abolfazl JokarAbstractVentilator-associated pneumonia (VAP) is one of the most important problems of intensive care units. 84 neurologic patients with acute stroke (Glasgow Coma Score ≤ 8) were entered into a double-blind clinical trial. Patients in the intervention group received piperacillin-tazobactam 4g/0.5g at the time of intubation and 12 hours later. The incidences of early-onset (within 4 days of intubation) and late-onset VAP were 9.2 and 26.9 episodes/1,000 days of mechanical ventilation in the intervention and control groups, repectively (OR, 0.217; 95% CI, 0.056 - 0.085; P = 0.028). Administration of prophylactic piperacillin-tazobactam may reduce early-onset VAP, but the benefit does not extend to late-onset VAP.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research