ABCC6 Deficiency Promotes Development of Randall Plaque

Conclusions
The frequency of kidney stones and probably, Randall plaque is extremely high in patients with PXE, and Abcc6–/– mice provide a new and useful model in which to study Randall plaque formation. Our findings also suggest that pyrophosphate administration should be evaluated for the prevention of Randall plaque and kidney stones.

Source: Journal of the American Society of Nephrology : JASN - August 31, 2018 Category: Urology & Nephrology Authors: Letavernier, E., Kauffenstein, G., Huguet, L., Navasiolava, N., Bouderlique, E., Tang, E., Delaitre, L., Bazin, D., de Frutos, M., Gay, C., Perez, J., Verpont, M.-C., Haymann, J.-P., Pomozi, V., Zoll, J., Le Saux, O., Daudon, M., Leftheriotis, G., Martin, Tags: Basic Research Source Type: research