The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models

The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL).

Source: Journal of Hematology and Oncology - August 25, 2018 Category: Hematology Authors: Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan and Jan Cools Tags: Research Source Type: research