'N-of-1-pathways' unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine.

CONCLUSIONS: The N-of-1-pathways framework provides a robust statistical and relevant biological interpretation of individual disease-free survival that is often overlooked in conventional cross-patient studies. It enables mechanism-level classifiers with smaller cohorts as well as N-of-1 studies.
SOFTWARE: http://lussierlab.org/publications/N-of-1-pathways.
PMID: 25301808 [PubMed - in process]

Source: Journal of the American Medical Informatics Association - October 16, 2014 Category: Information Technology Authors: Gardeux V, Achour I, Li J, Maienschein-Cline M, Li H, Pesce L, Parinandi G, Bahroos N, Winn R, Foster I, Garcia JG, Lussier YA Tags: J Am Med Inform Assoc Source Type: research