Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN- γ secreting cells.

CONCLUSION: Our data show an increased sensitivity of PBC and pSS Treg cells to low dose IL-12 stimulation, providing ongoing support for the importance of the IL12-IL-12Rβ2-STAT4 pathway on Treg cells in disease pathogenesis and potentially treatment.
PMID: 30119881 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - August 14, 2018 Category: Allergy & Immunology Authors: Liaskou E, Patel SR, Webb G, Bagkou Dimakou D, Akiror S, Krishna M, Mells G, Jones DE, Bowman SJ, Barone F, Fisher BA, Hirschfield GM Tags: J Autoimmun Source Type: research