Neuroprotective effects of bergenin in Alzheimer's disease: Investigation through molecular docking, in vitro and in vivo studies.

In conclusion, the observed effects might be attributed to the cholinesterase inhibitory activity of bergenin coupled with its antioxidant effect, anti-inflammatory activity and reduction of Aβ-1-42 and p-tau levels which could have collectively helped in the attenuation of cognitive deficits. The current findings of the study are indicative of the promising preventive and ameliorative potential of bergenin in the management of AD through multiple targets.
PMID: 30118774 [PubMed - as supplied by publisher]

Source: Behavioural Brain Research - August 14, 2018 Category: Neurology Authors: Barai P, Raval N, Acharya S, Borisa A, Bhatt H, Acharya N Tags: Behav Brain Res Source Type: research